人参附子青皮注射液对大鼠内毒素性休克的防治研究

作者	单位
张陈福	上海中医学院中医实验研究室
刘春元	上海中医学院中医实验研究室
卫洪昌	上海中医学院中医实验研究室
朱晓梅	上海中医学院中医实验研究室

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中文摘要:

本文用参附青注射液防治大鼠内毒素休克,证明静脉注射内毒素后立即滴注参附青注射液,血压保持原水平,滴注生理盐水组血压则持续下降至72.3±16.0 mmHg。对内毒素引起的低血压(80mmHg 以下)滴注参附青后上升至104.1±15.0mmHg,生理盐水组则无效(63.4±15.0mmHg)。内毒素与生理盐水分别从颈、股静脉滴注,可引起肠系膜微动脉收缩,参附青组则有显著拮抗作用。两组比较,滴注后90分钟 P<0.05,滴注后120分钟 P<0.01。提示参附青对早期内毒索性休克有较好的防治作用。

英文摘要:

53 Wistar rats were used for investigating the effect of PAC(Panax ginseng.Aconitum carmichaeli, Citrus tangerina)injection on cndotoxin shock.(1)Immediately after the endotoxin(4 mg/kg per rat)were injected intrvcnously into all animals,group A received 3 ml PAC injection given i.v.dripping,while group B received the same amount of saline.It revealed that the blood pressure of group A remained normal but that of group B was lowered significantly(t test:15′ t=1.077,P>0.05;30′ t=1.983,P>0.05;45′ t=3.21, P<0.01;60′ t=3.7.P<0.01).(2)After an injection of 4 mg/kg endotoxin,their blood pressure gradually dropped to 80 mmHg.And then group A received PAC injection and group B the saline.It was found that the blood pressure was normalized after PAC injection,while saline proved to be ineffective(t test:15′ t=5.73,P<0.001;30′ t=4.675,P<0.001;45′ t=3.74,P<0.01;60′ t=3.436,P<0.01):(3)Endotoxin was given via external jugular vein to all animals,and PAC was dripped into femoral vein of group A and normal saline to those of group B simultaneously.The change of mesenteric arteriole lumen was observed and measured by means of close circuit TV system.After 90 minutes,it was found that the change was 15.41±2.96μm in group A,and 12.08±2.57μm in group B(P<0.05).After 120 minutes it was 15.27±2.65μm and 11.25±2.25μm respectively(P<0.01).These data indicated that PAC injection was effective not only in preventing and treating endotoxin shock in rats,but also in inhibiting the constriction of mesenteric arteriole caused by endotoxin.

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