人参总皂甙对小鼠缺氧心肌乳酸和环核菩酸及超微结构的影响

作者	单位
方云祥	湖南医学院药理教研室
陈修	湖南医学院药理教研室
沈乃	湖南医学院药理教研室
刘哲生	湖南医学院药理教研室
丘泉滨	湖南医学院电镜室

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中文摘要:

人参总皂甙540mg/kg 腹腔注射能降低小鼠在严重缺氧情况下大脑和心肌的乳酸含量,能恢复缺氧时心肌 cAMP/cGMP 比值的降低,表明能改善组织在缺氧时的能量代谢。缺氧小白鼠心肌的超微结构观察显示,人参总皂甙能保护心肌毛细血管内皮细胞,减轻线粒体的损伤。以上结果说明人参总皂甙对小鼠缺氧时的代谢和超微结构损伤均有保护作用。

英文摘要:

Mice were placed in hermetically sealed flask for 10,20,30,40 min.or to a minimal residual oxygen content of 7%.The whole heart was used to determine the lactic acid,cAMP and cGMP level.Specimens from endocardium and apical part of heart were examined with electronmicroscope.The results revealed that ginsenosides(540 mg/kg ip)reduced the cerebral and myocardial lactic acid level and restored the reduction of cAMP/cGMP under severe anoxie state.The damage of myocardial capillaries and the ultrastructural change of mitochondria showed slight swelling,and nearly all of the capillaries remained normal.The present study suggests that ginsenosides protected both metabolic disturbances and ultrastructural damage of myocardium during severe anoxia.

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