高血压病肝郁证的临床研究

作者	单位
张问渠	中国中医研究院基础理论研究所中医辨证二室
孙恩亭	中国中医研究院基础理论研究所仪器分析室
谢小冰	中国中医研究院基础理论研究所生化室
阚甸嘉	中国中医研究院基础理论研究所病理室
傅湘琦	中国中医研究院基础理论研究所电镜室
宣清华	中国中医研究院基础理论研究所电镜室
刘学俊	中国中医研究院基础理论研究所电镜室
苏秉文	北京海淀医院

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中文摘要:

本文通过临床疏肝理气药对35例高血压病肝郁证患者的观察,降压总有效率达85.72%,紫黯舌有45.71%减退。实验研究发现,高血压病肝郁证患者血微量元素 Zn/Cu 比值治疗后显著下降;治疗前全血5-HT 含量明显高于健康人,治疗后接近正常数值。另外通过观察血小板超微结构、血小板凝聚率以及甲皱微循环治疗前后的变化,表明疏肝理气药有诱导血小板的解聚及改善微循环的作用。为探讨研究气滞在血瘀中的机理提供了依据。

英文摘要:

To make an objective study of syndrome,clinical experimental research on the syndrome of liver stagnation in hypertension has been done according to the liver’s functions of smoothing and regulating vital energy and blood volume under guidance of the TCM’s theory on Zang-Fu(脏腑),channel,vital energy and blood,and Yin-Yang(阴阳). 35 cases of patients with the syndrome of liver stagnation in hypertension were treated by herbs of invigorating liver and regulating vital energy.The total effective rate marked by decrease in blood pressure reached 85.72%,half of the patients’demonstrations were improved,purple brown tongue turned better in 45.71% of the patients,the rate of Zn/Cu decreased,and the content of 5-HT in blood became normal. Through the ultrastructure of blood platelets,their aggregating activity and microcirculation on nail bed,a certain degree of changes have been observed.The herbs of invigorating liver and regulating vital energy could depress the aggregation of the platelets and improve microcirculation.The studies suggest that liver stagnation not only has the demonstrations of the syndrome on vital energy stagnation,but also on blood stasis,and some indexes have shown coorelation to that syndrome,and provided scientific basis for mechanism of blood stasis caused by vital energy stagnation.

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