北芪注射液治疗慢性肾炎对蛋白尿、肾功能及免疫功能的影响

作者	单位
董德长	上海第二医科大学附属瑞金医院内科
周令芳	上海第二医科大学附属瑞金医院内科
侯国英	上海第二医科大学附属瑞金医院内科
陈金祥	上海南市区卫生学校
黄冬生	上海免疫研究所
李培成	上海中医学院附属龙华医院免疫室
王连琴	上海中医学院附属龙华医院免疫室

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中文摘要:

56例慢性肾小球肾炎患者使用北芪注射液一疗程后:肾病组:PHA-P、IgG、IgA 明显上升,尿蛋白明显下降;肾炎组:PHA-P 明显上升,尿蛋白明显下降;肾功能不全组:PHA-P、IgM、尿蛋白明显上升,血清 Cr、BUN 明显下降。表明北芪注射液有调节细胞免疫和体液免疫、降低尿蛋白、改善肾功能的作用。本药治疗尿蛋白的有效率为61.7%。

英文摘要:

56 patients of chronic glomerulonephritis divided into nephritic,nephrotic and renal insufficiency groups were treated with injection of North Astragalus membranaceus.One course of treatment consisted of 30 injec- tions,each with 2 ml intramuscular per day.Qualitative and quantitative measurements of proteinuria,renal function test,non specific cellular immunity PHA-pereutaneous(PHA-P)test,PHA induced lymphocyte trans- formation H 3 test(PHA-Tr),adenosine induced suppression assay(AISA),serum lgG,IgA,IgM,C3,C4, CH 50,ACH 50(factor B),CIC:PEG precipitating assay,C 1 q-ELISA,Clq binding assay,proteinuria in 24 h.,Cr, BUN were measured before and after treatment. Before treatment,PHA-P was evidently lower than normal controls,IgG and IgA were lower,and IgM was higher than normal in-nephrotic group.In uremia IgG,IgA and IgM were all lower than normal.C 3 decreased in 36/56,factor B was reduced in 13 correlatively with C 3.CIC positive in Clq ELISA,C lq BA and PEG-PA was 40.4%,40.8% and 32.1% respectively. After treatment,PHA-P increased,CIC tended to decrease but without statistical significance,and IgG and IgA increased in nephrotie group after 1 course.Increase in renal insufficiency group was found after 3 courses of treatment.The complement system improved but without statistical significance.Proteinuria decreased in nephritic and nephrotic groups;increase in the uremic group was parallel to improvement of the renal function, and decrease was found with successive treatment after 50 injections.The total effective rate was 61.7%. Based on the above observation,injection of North Astragalus membranaceus can improve cell-mediated and humoral immunity,reduce proteinuria and improve the renal function.It has certain effects in the treatment of glomerulonephritis patients.

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