活血化瘀药丹参治疗骨折的超微结构研究

Ultrastructural Observation on Experimental Fracture Treated with Principle of Promoting Blood Circulation and Relieving Stasis——A Transmission Electron Microscopic Study

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DOI：

中文关键词: 成纤维细胞骨折愈合丹参线粒体膜破骨细胞原纤丝蛋白质合成粗面内质网钙盐沉积骨生成细胞

英文关键词:

基金项目:

作者	单位
柴本甫	上海市伤骨科研究所
汤雪明	上海第二医科大学

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中文摘要:

本文观察丹参对家兔骨折修复的影响。X 线检查证实丹参可使骨折部位骨痂形成提前出现,且更为致密。透射电镜观察表明,丹参可使:(1)骨生成细胞分布部位及数量增加;(2)成纤维细胞除有外形改变外,细胞的蛋白质合成活动更为旺盛,细胞的正常变性过租也加快,细胞外胶原纤维增多,并进入成纤维细胞的胞质内;(3)有增多的破骨细胞出现在不同的骨痂部位,促进骨的改建;(4)成纤维细胞肿胀的线粒体内出现众多的致密钙颗粒,从而使骨痂有更多更早的钙盐沉积。

英文摘要:

In the course of healing the standardized fracture of radius in 50 New Zealand rabbits,an expeditious effect on repairing was achieved as a result of administration of Radix Salviae miltiorrhizae which exerted the action of promoting the blood circulation and relieving the stasis.X-ray study of the radial fracture revealed that callus formation appeared earlier and was denser as compared with another series of 50 control rabbits.As judged from the transmission electron microscope(TEM)observation,the favourable effects could be reflected in five aspects.Firstly,there was an increase in both the site of distribution and the number of the osteogenic cells.Secondly,the fibroblasts,in addition to their change in configuration,showed very active protein synthesis. There was also an expedition of the normal process of fibroblast degeneration.Thirdly,there was appearance of increased number of osteoclasts in different localities of fracture callus to promote remodelling.Fourthly,there was exuberant amount of collagen fibril formation in enhancing the production Of the organic matrix.Fifthly, there was numerous dense calcium granules in the swollen mitochondria of the fibroblasts so as to provide adequate supply of calcium for the calcification of the matrix vesicles and the collagen fibrils..

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