3,4-乙酰基间苯二酚和3,4-二羟基苯乳酸对大鼠肝脏微循环的影响

作者	单位
张清波	上海医科大学附属华山医院
孙涛	上海医科大学附属华山医院
邬祥惠	上海医科大学附属华山医院
沈自尹	上海医科大学附属华山医院
顾克仁	香港中文大学医学院生理系

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中文摘要:

毛冬青有效成分3,4-乙酰基间苯二酚(DHAP)与丹参的有效成分3,4-二羟基苯乳酸(DHPLA),它们在化学结构上均属4-儿苯酚衍化物。本文观察了合成的 DHAP与 DHPLA 对大鼠肝脏表面微循环及对胆汁分泌的影响,结果表明两者均可加快肝脏局部微循环血流及胆汁分泌。

英文摘要:

3,4-Dihydroxyacetophenone(DHAP)and 3,4-Dihydroxyphenyllactic acid(DHPLA),the natural compound from the Chinese medicinal herbs llex pubescens and Salvia miltiorrhiza,were synthetized for the study of their vascular and choleretic effects.Blood flow on the liver surface was monitored by a Laser-Doppler flowmeter,control flow value was taken as 100 %.Bile secretion rate was measured with a drop counter from a cannula in the common bile duct.Results showed that both drugs significantly increased hepatic blood flow and bile secretion rate in dose-dependent manner,the DHPEA was more potent than DHAP in enhancing hepatic blood flow,while the DHAP was more potent than DHPLA in enhancing choleretic action.

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