人参和三七对小鼠记忆的易化作用

本文采用一次性训练被动回避性条件反应和水迷宫法,观察了人参及三七根20%乙醇提取物对小鼠学习记忆的改善作用。结果表明;人参可拮抗樟柳碱和戊巴比妥钠造成的记忆获得不良,改善环己酰亚胺和亚硝酸钠造成的记忆巩固障碍以及40%乙醇造成的记忆再现缺损;三七亦可拮抗樟柳碱造成的记忆获得不良和改善亚硝酸钠造成的记忆巩固障碍,但对戊巴比妥钠造成的记忆获得不良和酒精引起的记忆再现困难则无作用。可见,人参与三七均可改善小鼠学习和记忆,但人参明显优于三七。

英文摘要:

Panax ginseng has been used as a tonic in TCM for several thousand years.Recent pharmacological studies suggested that ginseng has various effects,e.g.,the stimulation or inhibition of the central nervous system,the regulation of endocrine function and the carbohydrate,fat and protein metabolism,the anti- fatigue as well as memory-enhancing effects,etc.On the basis of these researches,studies of ginseng on learning and memory were carried out.Because Panax pseudoginseng is similar to ginseng in many chemical components,a comparison of the pharmacological effects between these two drugs was also made. 20% alcohol extracts of ginseng and pseudoginseng roots were used in mice for facilitation of memory using one trial passive avoidance responses and water maze methods.The results indicated that ginseng improved impairment of acquisition of memory produced by anisodine and pentobarbital,and disruption of consolida- tion of memory caused by cycloheximide and sodium nitrite,and it was also capable of antagonizing alcohol-induced deficit of retrieval.Similar effects were observed with pseudoginseng in the case of impairments of acquisition of memory caused by sodium nitriteand anisodine.It is obvious that ginseng is more effective than pseudoginseng on learning and memory in mice,The study on the mechanism of action of ginseng and pseudoginseng in promoting learning and memory is being carried on.

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