异叶败酱挥发油镇静作用的研究

作者	单位
马越美	北京医科大学药学院生药学教研窒
齐治	北京医科大学药学院生药学教研窒
崔景荣	北京医科大学药学院生药学教研窒
楼之岑	北京医科大学药学院生药学教研窒

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中文摘要:

本文观察了败酱科植物异叶败酱根和根茎中制得的挥发油的镇静和安眠作用。结果表明,此油灌胃给予数组小鼠,剂量0.25ml/kg,显示如下的作用:(1)显著延长由于腹腔注射戊巴比妥钠40mg/kg 引起的睡眠时间,其强度与黄花败酱挥发油基本相同。(2)显著增加由腹腔注射戊巴比妥钠阈下剂量(25mg/kg)引起的阳性反应率。(3)显著增加小鼠肝匀浆中细胞色素P-450的含量。上述结果表明,异叶败酱挥发油具有中枢性镇静作用。一次灌胃给予小鼠大剂量(5.0ml/kg)的异叶败酱挥发油,连续观察6天。动物无一死亡,外观正常,仅体重增加较少。

英文摘要:

The volatile oil prepared from the root and rhizome of Patrinia scabiosaefolia Fisch has been reported previously to possess sedative and hypnotic action and was effective for the treatment of neurasthenia and neurasthenic syndromes with insomnia as the chief symptom.This paper deals with the sedative and hypnotic action of the volatile oil obtained from the root and rhizome of a related species Patrinia heterophylla Bunge.The oil at a dose of 0.25 ml/kg given orally to groups of mice produced the following effects:(1)A significant increase in prolonging the sleeping time induced by pentobarbital sod.40 mg/kg,i.p.,its activity being practically the same as that of the volatile oil isolated from P.scabiosaefolia,(2)A significant increase in the number of hypnotized animals induced by an subthreshold dose of pentobarbital sod.,25 mg/kg,i.p.;(3)A significant increase in the content Of cytochrome P-450 in liver homogenate of mice.The above results showed that the volatile oil of Patrinia heterophylla possessed a sedative effect due to its action on the central nervous system.A large dose of the volatile oil,5.0 ml/kg(20 times of its effective dose),was given orally to a group of mice and its effects observed for six successive days.The result showed that the animals well tolerated with such a large dose of drug.body-weight slightly increased,and no animal died.

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