| 邝安堃,陈家伦,陈名道,丁霆,李凤英,唐金凤,朱忠义,金静芬,陈梦月,周建中,邱宏霞.助阳、清热养阴中药对实验性低甲及高甲大鼠血清TRH、T3、T4的影响[J].中国中西医结合杂志,1987,(11):674-675,646 |
| 助阳、清热养阴中药对实验性低甲及高甲大鼠血清TRH、T3、T4的影响 |
| Effects of Yang-Restoring and Yin-Nourishing Herbs on Serum TRH,T3 and T4 Levels in Experimental Hyperthyroid and Hypothyroid Rats |
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| DOI： |
| 中文关键词: 助阳药 正常大鼠 清热养阴 甲状腺激素 大鼠血清 实验性 中药 甲状腺素 干甲状腺片 用药 |
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| 中文摘要: |
| 切除双侧甲状腺大鼠血清 T3,T4下降,TRH 升高,垂体重量增加（P 均<0.001）。用助阳药可使 T4较不用药组增高,垂体重量较低（P 均<0.01）,TRH 较低（P<0.001）,但助阳药使正常大鼠 T3下降（P<0.001）,TRH 升高（P<0.002）。饲用甲状腺片造成高甲状腺素状态大鼠 T3,T4升高,TRH 下降,用清热养阴药后使 T4较不用药组下降（P<0.05）。 |
| 英文摘要: |
| Hypothyroid rats[Yang（阳）deficiency model]were prepared by bilateral thyroidectomy while hyperthyroid rats[Yin（阴）deficiency model]were induced by feeding dessicated thyroid 160 mg/day per rat.Yang-restoring herbs（Codonopsis pilosula,Astragalus membranaceus.Epimedium brevicor- num,Aconitum carmichaeli,Cinnamomum cassia and Cistanche deserticola）could increase reduced T4 level（P<0.01）and decrease elevated serum TRH level（P<0.001）in hypothyroid rats.The weight gain of pituitary in hypothyroid rats also decreased by these herbs（P<0.01）.However.in normal rats,Yang-restoring herbs could decrease serum T3 level（P<0.001）and increase serum TRH level （P<0.02）.Yin-nourishing herbs（Gentiana scabra,Dendrobium nobile.Coptis chinensis,Rehmannia glutinosa,Codonopsis pilosula,Astragalus membranaceus）could decrease elevated serum T4 level（P< 0.05）in hyperthyroid rats.There was no effect of Yin-nourishing herbs on T3,T4,and TRH levels of normal rats.These results indicate:（1）Yang-restoring and Yin-nourishing herbs were effective respectively in the treatment of Yang deficiency and Yin deficiency animal models.（2）Yang-restoring herbs might exert an unfavorable effect on normal animals without Yang deficiency symptoms.The mechanisms remain to be elucidated. |
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