脉络宁治疗三种血栓病的疗效观察及其机理探讨

作者	单位
顾亚夫	江苏省中医研究所周围血管病科
赖尧基	江苏省中医研究所周围血管病科
倪正	江苏省中医研究所周围血管病科
佟慕新	南京神经精神病防治院
杨秀冰	南京中医学院附属医院
杨能华	江苏省中医研究所周围血管病科
孙加洪	江苏省中医研究所周围血管病科
张志远	江苏省中医研究所周围血管病科
蔡雪珠	江苏省中医研究所周围血管病科
吴垦莉	江苏省中医研究所周围血管病科

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中文摘要:

本文报道脉络宁治疗血栓闭塞性脉管炎157例、深静脉血栓形成73例及脑血栓形成52例,临床总有效率分别为97.5%、100%及88.4%。临床研究结果表明:脉络宁具有扩张血管,促进血液循环,提高纤溶活性,改善血液粘滞性和高凝状态,有抗凝与防止血栓形成等作用

英文摘要:

Mailuonin(MLN)is a compound preparation of medicinal herbs.The main drugs of this prepon are Scrophularia ningpoensis,Achyranthes bidentata and other two drugs,which has a good therapeutic effect and no apparent side-effect.Results:(1)82.8%(130/157)of thromboangiitis obliterans patients belonged to Ⅲ phase,clinical cure and markedly effective of which amounted to 148 cases,94.25%.(2)73 cases of deep vein thrombosis of lower limb,the total number of their clinical cure and markedly effective were 61 cases,83.8%;12 cases improved,16.4%.(3)52 cases of cerebrothrombosis:Course of disease of 39 cases was within 6 months,the rate of basic cure and markedly improved were similar to 35 cases of the control group treated with low molecular dextran. 11 cases′courses were over 1 year;they obtained satisfactory effect also,which denotes that MLN is effective in treating sequelae of cerebro-thrombosis as well.The mechanisms of MLN were as follows:(1)It might increase the activity of fibrinolysis and the electrophoresis of erythrocytes and thrombocytes,reduce the blood viscosity and lower the coagulability tendency,which showed that the MLN has the function of anticoagulation and anti-thrombosis.(2)After treatment the ratio of serum cGMP/cAMP was raised,which means the production of cholinergic effect.The biochemical and pharmacological experiments revealed that MLN caused excitation of histamine and cholinergic receptors as well as the inhibition of adrenergic receptors,consequently vasodilation and increase of blood flow occurred.At the same time,it normalized the disturbance of patient’s nailfold microcir- culation.

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