藁本中性油的镇静、镇痛、解热和抗炎作用

作者	单位
沈雅琴	陕西省中医药研究院中药药理研究室
陈光娟	陕西省中医药研究院中药药理研究室
马树德	陕西省中医药研究院中药药理研究室

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中文摘要:

本文对西芎藁本中性油进行了镇静、镇痛、解热和抗炎的初步药理实验。结果表明其能抑制小鼠的自发活动及对抗苯丙胺引起的运动性兴奋,能加强硫贲妥钠的催眠作用,能对抗酒石酸锑钾引起的小鼠"扭歪反应"及明显延长热板反应的时间,并降低致热动物的体温及正常小鼠的体温,还能对抗二甲苯性炎症。推测藁本中性油可能是藁本药理作用的有效成分之一。

英文摘要:

The spontaneous activity,and the excitatory activities induced by amphetamine sulfate in mice could be inhibited significantly;by oral administration of neutral oil isolated from Ligusticus sinensis （NOLS）.Orally administered with NOLS,the sleeping time of mice induced by thiopental sodium was prolonged and the number of writhing of mice induced by potassium antimony tartrate was reduced and pain threshold of mice in hot-plate test was raised.The NOLS possessed a marked antifebrile effect.The fever of rabbits and mice was induced by injecting typho-paratyphoid vaccine.The rectal temperature was markedly reduced by oral administration of NOLS.The rectal temperature of normal mice also could be reduced by it.Furthermore,NOLS possessed an anti-inflammatory effect. Swelling of mice’s ear induced by xylene was inhibited by the NOLS.The acute toxicity test showed that LD₅₀in mice of NOLS was found to be 70.17±4.95 g/kg（crude drug）. The above data revealed that the NOLS possessed effects of sedation,analgesia,antipyrexia and anti-inflammation.The results also indicated that NOLS was one of the active ingredients of Ligusticus sinensis.

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