| 张晓星,竺稽能,朱普年,艾陵,王喜云,谭大琦,严春海,陈振发,沈远鸣.舒心宁治疗冠心病的临床与实验研究[J].中国中西医结合杂志,1988,(1):24-26,5 |
| 舒心宁治疗冠心病的临床与实验研究 |
| Clinical and Experimental Investigation of Shuxinning in Treating the Coronary Heart Disease |
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| DOI： |
| 中文关键词: 冠心病心绞痛 垂体后叶素 治疗后 心电图 对照组 耐缺氧能力 有效率 实验研究 心肌缺血 陈旧性心肌梗塞 |
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| 中文摘要: |
| 对62例冠心炳患者随机分为两组,治疗组服用舒心宁糖浆,对照组服用焦糖。结果:治疗组心绞痛有效率96.5%。对照组27.6%。治疗组心电图好转率46.1%,对照组14.3%。治疗组疗效优于对照组(P<0.01)。实验研究表明:舒心宁对家兔实验性心肌梗塞有缩小梗塞面积作用;有对抗由垂体后叶素引起小鼠心肌缺血作用;增加离体豚鼠心脏冠脉流量;明显增加心脏对(86)~Rb 的摄取率;提高小鼠耐缺氧能力及抗血小板聚集等作用临床及毒理试验均证实舒心宁无毒性,副作用小,为舒心宁治疗冠心病提供了依据。 |
| 英文摘要: |
| 62 coronary heart disease(CHD)patients were divided into two groups at random.Shuxinning (SXN,a complex prescription of TCM)was administered to the treated group,while brown sugar to the control group.The results:The symptom of angina pectoris was relieved in both treated and control groups,the rates of which were 96.5% and 27.6% respectively.The ECG improvement rates were 46.1% and 14.3% respectively.The experimental animals were also treated with SXN,and it showed that the SXN could yield the following effects:The area of myocardial infarction in rabbits became smaller,and the protection from pituitrin-induced myocardial ischemia in rats,the increase of blood flow in isolate heart of guinea pigs,the elevation of(86)~Rb uptake rate of mice’s heart,the rise of anoxia tolerance in mice,and the anti-agglutination of platelets were significant.Both clinical and toxicological tests showed that SXN was non-toxic and had few side-effects.Therefore this paper provides a scientific basis for the use of SXN in treating CHD. |
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