雷公藤片治疗多发性硬化的初步探讨

作者	单位
孙嘉斌	哈尔滨医科大学附属第一医院神经科
葛茂振	哈尔滨医科大学附属第一医院神经科
吴长有	哈尔滨医科大学免疫学教研室
王文余	哈尔滨医科大学免疫学教研室

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中文摘要:

本文报道32例多发性硬化患者分别用雷公藤片、氟美松、ACTH 和维生素类药物治疗。结果表明,雷公藤片有较明显的改善临床症状和调节免疫功能的作用。雷公藤组10例患者中,8例症状明显缓解,2例轻微缓解。雷公藤片治疗后患者血清中 CIC、抗 MBP 抗体和 CNS IgGsyn 水平较治疗前均显著下降,P<0.01、P<0.01和 P<0.05。治疗后血清补体 C₃水平比治疗前显著升高,P<0.01。

英文摘要:

This paper reports on 32 multiple sclerosis patients treated with Tripterygium wilfordii tablets （TW）,dexamethasone or ACTH（as positive control）and vitamin B,C tablets（as negative control）, to study the clinical effects of TW and differences in humoral immunological function of the patients before and after treatment.The results suggested that TW had obvious effects in relieving clinical symptoms and regulating immunological function of those patients who were treated with it.In 8 of the 10 cases in the TW group,symptoms were significantly relieved and signs were recovered.In the other two cases,symptoms were slightly alleviated.In 9 of the 11 cases in the dexamethasone group, symptoms were relieved,1 case ineffective,and one was aggravated,which improved after treated with TW.4 out of 7 cases in the ACTH group were relieved,but 2 cases showed no Change and one aggravated.None of the 4 cases in vitamin group improved.The levels of serum CIC and MBP antibody of the patients treated with TW decreased significantly（P<0.01）after treatment,while the levels of C₃ increased significantly（P<0.01）.7 cases in the TW group had abnormally high levels of CNS IgG syn before treatment,which were reduced significantly after treatment（P<0.05）.Although the levels of serum CIC and MBP antibody of the dexamethasone and ACTH groups were decreased, but there was no increase in C₃,and some side-effects were present.The results showed that TW tablets had corticosteroid-like effects but without corticosteroid-like side-effects,it could increase levels of C₃ and relieve the clinical symptoms.

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