中西药物治疗妊娠高血压综合征的疗效分析

125例妊娠高血压综合征、妊娠高血压及妊娠水肿患者,分为用药组50例,对照组75例。结果:分娩期高血压、水肿消失者用药组为22例(44%),对照组为20例(26.7%),P<0.05;分娩期妊高征用药组由31例减为24例,对照组则由26例增加到34例。妊高征、妊高肿评分指数:用药组治疗前(6.32±2.41、1.68±0.89)与分娩期(6.94±5.25、1.84±0.89)相比,P>0.05;对照组治疗前与分娩期(4.29±1.70、1.83±1.30与9.38±6.20、6.50±6.76)相比,P<0.01。上述表明,用药组经中西药物治疗病情基本稳定,且中药组疗效优于西药组。

英文摘要:

125 cases of hypertensive disorder in pregnancy,gestational hypertension and gestational edema treated at the out-patient department in 1984 were reported.50 of them received drug treatment and were advised to take bed rest by lying on their left side.75 patients were advised to comply with the same bed rest program but were not treated with drugs.To compare the pregnancy outcomes of the two groups,criteria were established for scoring and classification.No difference was found between these two groups in age,parity,gestational weeks at onset of disorders,etc.The score of the medicated group(with two subgroups)was significantly higher than that of the non-medicated group. In the first sub-group of the medicated group,based upon the theory of TCM,the principles of replenishing the Kidney and reinforcing the vitality,nourishing both the Kidney and Liver Yin(阴), and activating the blood circulation and relieving the stasis were followed.Salvia miltiorrhiza, Cuscuta chinensis,Rehmannia glutinosa,Paeonia rubra.Agastachis rugosus,Scutellaria baicalensis, Ophiopogonis japonis were taken as basic recipe,added with Codonopsis pilosula,Astragalus membranaceus,Poria cocos and Dipsaci asper as recipe No.1,and added with Eucommia ulmoides as recipe No.2.In the second sub-group,phenergan,salbutamol,folic acid,vitamin E and C were prescribed.Data collected at the time of delivery showed that 5 cases(10%)in the medicated group and 22 cases(29.23%)in the control were admitted because of exacerbation of the disease.44% of the patients in the medicated group no longer had either hypertension or edema,being significantly higher than that(26.7%)in the non-medicated group.The scores of the pregnancy outcomes of the TCM group(3.84±3.37)and WM group(9.93±5.24)showed statistically significant difference(P<0. 02).At the termination of pregnancy patients with the hypertensive disorder of pregnancy decreased from 31 to 24 in the medicated group;whereas in the non-medicated group the number of the same disorder increased from 26 to 34.In the TCM group the moderate and severe patients decreased from 4 to 2;while in the WM group it increased from 3 to 8.It revealed that the drug treatment was more effective than the control,and TCM treatment was more effective than WM treatment.No maternal death was recorded.One case in the control developed postpartum eclampsia.No recurrence of hypertension was noted in 1-year follow-up examination.There was one perinatal death(8‰)from the non-medicated group.

关闭