阿魏酸钠对冠心病患者血小板聚集及血小板TXA<sub>2</sub>的影响

作者	单位
高树伟	中国医学科学院心血管病研究所
陈在嘉	中国医学科学院心血管病研究所
陶寿淇	中国医学科学院心血管病研究所
徐理纳	中国医学科学院药物研究所

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中文摘要:

本文报道观察阿魏酸钠对冠心病患者血小板功能影响的结果,表明阿魏酸钠在体外可显著抑制血小板聚集及血小板 TXA₂生成,其作用呈浓度依赖型。阿魏酸钠4mg/kg 静脉滴注未观察到对冠心病患者血小板功能有显著影响,可能与剂量不足有关。

英文摘要:

Sodium ferulate（SF）,one of the active principles of Angelica sinensis,was investigated in vitro and in vivo for its anti-platelet effects.In vitro,SF inhibited platelet aggregation was induced by epinephrine or ADP as well as inhibited platelet TXB₂（a metabolite of TXA₂）generation,which occurred in the platelet rich plasma of patients with CHD,in a dose dependent fashion.At low concentration,SF showed a markedly inhibitory effect on platelet TXB₂ generation more than that on platelet aggregation.While at a higher concentration,platelet aggregation was more evidently suppressed than platelet TXB₂ generation.The results suggest that SF,in vitro,could effectively inhibit the platelet aggregation in patients with CHD,which was partly related to the inhibition of TXA₂ generation.SF was also intravenously infused,in a dosage of 4 mg/kg.However,both 6-keto-PGF_1aand TXB₂ in plasma and in serum remained unchanged;platelet aggregation and platelet TXB₂ generation were lower than the values measured before SF infusion,but,as compared with placebo,no significant difference statistically was observed.Inadequate dosage might be the main cause for the failure.

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