| 侯愚,李淑梅,孟晓萍,刘文富,陈翠兰,陈滴,杨晓红,张培因,杨维三.薤白提取物胶丸防治动脉粥样硬化的临床观察[J].中国中西医结合杂志,1988,(5):266-267,259 |
| 薤白提取物胶丸防治动脉粥样硬化的临床观察 |
| Clinical Observation on Anti-Atherosclerosis Effect with Allium nerimifolium Extract,Capsule |
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| DOI： |
| 中文关键词: 动脉粥样硬化 前列腺素 血小板聚集率 原发性高脂血症 提取物 新型药物 脂蛋白 防治 血小板聚集抑制 抑制血小板聚集 |
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| 中文摘要: |
| 132例高脂血症患者口服薤白提取物胶丸4周后,比较服药前后血浆总胆固醇、β脂蛋白、血浆6-酮-前列腺素 F1α的变化,P 值均<0.001;血小板聚集率服药前后对比 P<0.01,表明该药有降低血脂、提高6-酮-前列腺素 F1α水平、抑制血小板聚集的作用,为防治动脉粥样硬化提供了一个有效的新型药物。 |
| 英文摘要: |
| Allium nerimifolium（AN）is a kind of wild vegetable widely taken for food in the countryside. It was recorded in TCM books that it was treated in relieving chest pain.The active principles of AN have been isolated.One of these principles,methylallyl compound,is an effective agent in inhibiting platelet aggregation and prouducing thromboxane A2（TXA2）.Recent data showed that AN contains prostaglandin A1（PGA1）.The AN capsule is the extract of AN supplied by the pharmaceutical department of our university.The capsule has been used in our hospital for more than three years.The criteria for diagnosis of primary hyperlipidemia were:plasma total cholesterol （TC）250mg/dl,trinitroglycerin（TG）≥160 mg/dl and β-lipoprotein（β-LP）≥450mg/dl,any one of the above items reached these values,and hyperlipidemia could be diagnosed.0.5 mg of AN per os,3 times a day was given to 132 patients with hyperlipidemia for 4 weeks.During thisperiod,no other drugs inhibiting platelet aggregation or decreasing plasma lipid were administered,and all of the patients were allowed to take their ordinary food as usual.Plasma lipid,6-keto-prostaglandin F1a (6-k-PGF1a)and platelet aggregation（PAg）were measured before and after the treatment.The main results were as follows:before administration the average of TC,TG,β-LP and 6-k-PGF1awere 262.9±56.4,162.7±87.1,421.9±114.2 and 1296.95±106 pg/ml respectively,and after medication 197.7±51.4,141.3±37.3,334.5±110.0 and 3271.12±579 pg/ml respectively.Platelet aggregation assay was performed in 8 out of 132 cases.PAg values were 51.66±25,and 26,85±16 respectively before and after treatment.The average inhibitionrate was 47.36%.The,results showed that administration of AN capsule could lower the levels of plasma TC,TG,β-LP and elevate the level of 6-k-PGF1a,P< 0.01.It also inhibited PAg at the same time.It is well known that hyperlipidemia and hypercoagula- ble state of the blood are very important pathogenetic factors of atherosclerosis,while 6-k-PGF1a,a stable metabolic product prostaglandin I2（PGI2）,is an effective,platelet aggregation inhibiting agent and also a potent coronary artery dilating agent.It is concluded that the AN capsule is obviously effective in preventing the pathogenesis of atherosclerosis. |
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