女性绝经后Ⅱ型糖尿病患者血浆性激素变化和中医辨证论治的疗效

作者	单位
邝安堃	上海市内分泌研究所
陈家伦	上海市内分泌研究所
陆永仁	上海市内分泌研究所
陈梦月	上海市内分泌研究所
张美云	上海市内分泌研究所
周长梅	上海市第八人民医院
汪蓓娟	上海市瑞金路地段医院
李澍芳	上海市打浦桥地段医院

摘要点击次数: 1372

全文下载次数: 948

中文摘要:

40例绝经后Ⅱ型糖尿病患者,血浆雌二醇（E₂）平均浓度42.4pg/ml,显著低于正常绝经对照组（51.8pg/ml）,P<0.02;血浆睾酮（T）平均浓度29.3ng/dl,也低于对照组（34.4ng/dl）,P<0.05;血浆孕酮（P）平均浓度0.97ng/ml,与对照组无显著差别,P>0.05。伴心血管并发症者（10例）与无明显并发症者（30例）相比 E₂较低,分别为38.4和44.6pg/ml,P<0.05。28例糖尿病患者加用以补肾为主的中药治疗三个月后,肾虚证明显好转,空腹血糖（FBS）平均由237降至164mg/dl,P<0.01;E₂下降,P<0.01;但雌酮、T、P 上升,P 均>0.05。

英文摘要:

40 cases of postmenopausal type Ⅱ diabetics were reviewed The mean age of these patients was 59.6 years;the period after the menopause was 12 years and the history of diabetes mellitus 6 years. The blood glucose was not well controlled although diet restriction was performed and tolbutamide given.As compared with the normal controls,the fasting blood glucose and triglyceride of the diabetes were significantly higher;plasma progesterone,also higher,while the estradiol and testos- terone,lower.The estradiol and progesterone of diabetics with cardiovascular complications were lower than those without.In addition to diet control and tolbutamide,28 diabetics were treated with traditional Chinese herbs which mainly nourished Kidney for 3 months and improved considerably. Among these patients the fasting blood glucose and triglyceride decreased significantly(P<0.01,P< 0.05 respectively).Estrone,testosterone and progesterone increased and estradiol decreased. In this series all the 28 cases had the manifestation of Kindney deficiency.The facts suggested that in females the decline of sex hormones played an important role in the pathophysiology of Kidney deficiency.Fewer females got coronary heart disease before menopause than males of the same age.This meant that in females the estrogens of physiological level was protective to cardiovascular system.In our series these postmenopausal diabetics improved after the therapy of nourishing Kidney,their phsma testosteone and progesterone increased,but the estradiol decreased paradoxically,probably it is due to the insufficient duration of treatment with traditional medicine and old aged patients with severe-diabetes.

关闭