肺部疾病辨证与鼻腔脱落细胞变化的初步研究

本文报告对患下呼吸道疾病分属肺气虚、肺阴虚、肺实证者大体正常的鼻腔进行脱落细胞检查,观察脱落细胞总数及鳞状上皮细胞、柱状纤毛细胞、嗜中性粒细胞的数量变化,并与健康人对照。发现下呼吸道病变对鼻腔脱落细胞有显著影响,这种影响存在证型和性别的差异。认为鼻腔脱落细胞检查能在一定程度上反映下呼吸道的病变状况,并可作为肺部疾病辨证的参考客观指标。

英文摘要:

This paper reports the changes of nasal cavity exfoliative cells consisted of the total cell, epithelial cell,ciliated cell and neutrophil count in patients who suffered from lower respiratory tract diseases,the"lung diseases"in TCM,which belonged to the syndromes of lung-Qi(气)deficiency lung-Yin(阴)deficiency and lung excess.A group of healthy subjectswas taken as control.All of the observed subjects had no nasal symptoms whatsoever and abormalities in nasal cavity in macroscop- ical observation as well.The results showed that lower respiratory tract diseases significantly affected the nasal cavity,and this was influenced by different syndrome types and sexes.(1)The squamous epithelial cell count had no significant difference among the four groups.(2) The neutro- phil count in lung-Qi deficiency group was Iower than that of the control(P<0.01),which indicated that there was a parellel relation of neutrophil between the nasal secretion and blood.(3)The ciliated cell count was increased in the two groups of lung deficiency,which was significantly higher than that of the control(P<0.01).It showed that the mucous membrane of nasal cavity was impaired in these patients.(4)In females,the Ciliated cell count was significantly increased in the three studied groups than the control(P<0.05,P<0.01),but in males of lung excess group it was similar to that of the control(P>0.05).This meant that the female’s nasal cavity was more susceptible in lower respiratory tract diseases.(5)Although there were considerable variation in the above-mentioned three kinds of cell count,but the total cell count of nasal cavity exfoliative cells among 4 groups showed no significant difference,which revealed that the influence of lower respiratory track diseases on nasal cavity was mainly reflected in the changes of cellular properties and the ratio of cells in nasal cavity mucous membrane.The defence functions of nasal cavity were impaired by these changes,which should be one of the physio-pathological basis that the patient was susceptible to cold when the patient suffered from lung deficiency.

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