| 刘忠铭,戴绍东,林国珍,卢尔滨,何敏,魏大愚,孙晶.麝香心脑乐治疗345例冠心病的临床观察及实验研究[J].中国中西医结合杂志,1988,(6):338-340,324 |
| 麝香心脑乐治疗345例冠心病的临床观察及实验研究 |
| A Clinical Study on 345 CHD Patients Treated with Shexiang Xinnaole |
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| DOI： |
| 中文关键词: 心脑乐 冠心病 心电图 临床观察 实验研究 心律失常 劳力型心绞痛 急性心肌缺血 治疗前后 血小板最大聚集率 |
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| 摘要点击次数: 1430 |
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| 中文摘要: |
| 用麝香心脑乐治疗冠心病345例,缓解心绞痛总有效率为88.1%,改善心电图心肌缺血总有效率为72.9%。实验证实该药有改善急性心肌缺血作用,能增加心肌营养性血流量,降低全血及血浆粘度,改善血小板最大聚集率,是一种安全有效治疗冠心病的新药。 |
| 英文摘要: |
| Shexiang Xinnaole tablet is a kind of compound drug consisted of several expensive Chinese herbs including Moschus moschiferus,Borneolum syntheticum,Ginsenoside,Panax pseudoginseng and Epirnedium brevicornum,etc.Each tablet weighed 0.3g,Containing 1.6g of crude medicine,4 tablets thrice per day for three weeks composed a course,orally taken.In this paper,345 cases of CHD were treated with a good result:88.1% of angina pectoris were relieved,72.9% of myocardial ischemia in ECG were improved and 70.4% of cardiac arrhythmia were alleviated.It was obviously superior to that of Xinshule(心舒乐)group as previously published,decreasing blood viscosity from 5.27±0.91 to 4.41±0.75(P<0.01),plasma viscosity from 1.81±0.20 to 1.62±0.18(P<0.01),rate of RBC electrophoresis from 0.85±0.18 to 0.98±0.17μm/sec/v/cm(P<0.01)and the platelet agglutination rate lowered from 27.32±12.14% to 22.06±11.12%. In conclusion,this drug could lower both blood and plasma viscosity,improve maximal platelet agglutination rate,it exerted also good effect in reducing myocardial ischemia,increasing nutritious blood flow to the myocardium.As to the rat myocardial uptake rate of(86)~Rb,there is a significant difference between pre-and post-experiment(3.30±0.39% and 2.96±0.35% respectively,P<0.01)as well as in treated and control groups(2.32±0.30% vs 1.67±0.23%,P<0.001). |
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