川芎红花注射液对百日咳菌液所致兔脑水肿的作用

作者	单位
张宝林	湖南医科大学第一附属医院儿科研究室
虞佩兰	湖南医科大学第一附属医院儿科研究室
徐正谷	湖南医科大学第一附属医院儿科研究室
李颖艳	湖南医科大学第一附属医院儿科研究室
喻建强	湖南医科大学第一附属医院儿科研究室

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中文摘要:

本实验观察川芎红花注射液对百日咳菌液所致兔脑水肿的作用。结果表明:川芎红花注射液对减轻血脑屏障的损害,降低脑血管的通透性,减少血浆成分从血管渗出有一定作用。为临床治疗血管源性脑水肿以及其他原因导致血脑屏障损害的一类疾病,提供了初步的实验依据。

英文摘要:

Clinically,the mortality and morbidity rates of the children with acute brain edema are relatively high.For the purpose of reducing the rate of mortality of this disease,the effects of Ligusticum-Carthamus injection with the model of rabbits’cerebral edema induced by pertussis bacillus suspension which is similar to the cerebral edema of children induced by infections and this method was originated in our research department.The experimental results showed that Ligusticum and Carthamus injection can reduce the injury of blood brain barrier(BBB)and the permeability of cerebral vessels,but it appears that effect of reducing intracellular edema is less than that of the former(BBB).In this article,it affords a primary experimental bases for the treatments of vasogenic brain edema and the diseases with injury of BBB induced by other causes.

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