阿魏酸钠抗兔急性氧中毒脂质过氧化

作者	单位
傅正恺	北京医科大学人民医院呼吸内科
赵德恒	北京医科大学人民医院呼吸内科
徐光华	海军总医院高压氧科
徐理纳	中国医学科学院药物所药理室
方允中	中国军事医学科学院放射医学研究所
刘智峰	中国军事医学科学院放射医学研究所

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中文摘要:

本实验通过对血浆 MDA 和全血 SOD 的检测,观察阿魏酸钠对兔急性氧中毒的抗脂质过氧化作用。实验结果:3只兔常压吸纯氧72小时,2只死亡;3只兔吸纯氧加注射阿魏酸钠无一死亡。吸纯氧72小时后血浆 MDA 明显增加(P<0.05);加用阿魏酸钠组血浆DMA 较吸纯氧前明显减少(P<0.01)。故中药阿魏酸钠对实验性急性氧中毒兔有明显保护作用。

英文摘要:

9 albino rabbits were divided into 3 groups to observe the effect of sodium ferulate(SF)in the treatment and prevention of acute oxygen intoxication and lipid peroxidation. Group(1)3 rabbits inhaled normal air serving as control;Group(2)3 rabbits inhaled pure oxygen continuously;Group(3) 3 rabbits inhaled pure oxygen and received sodium ferulate 50 mg/kg every day at the same time. After 72 hours of experimentation,2 of the 3 rabbits of group(2)died of acute oxygen intoxication and their plasma malondialdehyde(MDA)showed remarkable increase than the control(P<0.05). While in group(3),no death happened and plasma MDA showed significant decrease than the control (P<0.01).There was no change in the control group.The results revealed that SF exhibited remarkable protection to acute oxygen intoxication of the rabbits by decreasing the lipid peroxida- tion.

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