丹参对冠心病患者微循环、2,3-DPG的影响及实验研究

作者	单位
俞国瑞	上海第二医科大学附属仁济医院
张世华	上海第二医科大学附属仁济医院
陆惠华	上海第二医科大学附属仁济医院
郑道声	上海第二医科大学附属仁济医院
陈铭生	上海第二医科大学附属仁济医院
徐依敏	上海第二医科大学附属仁济医院
谢秀兰	上海第二医科大学附属仁济医院
徐顺潮	上海市激光技术研究所
夏罗林	上海市激光技术研究所
宋佩英	上海市激光技术研究所
王钧培	上海市激光技术研究所
江时森	南京军区总医院

摘要点击次数: 1162

全文下载次数: 924

中文摘要:

本文应用激光多普勒显徽血流计测定冠状动脉狭窄患者和兔急性微循环障碍时微血管血流速度,测定冠状动脉狭窄患者全血和红细胞2,3-DPG 的变化,测定急性缺氧大白鼠2,3-DPG 和血气分析,并观察丹参对动物和冠状动脉狭窄患者上述参数的影响结果显示,丹参可增加冠心病患者和动物的血流速度和全血及红细胞2,3-DPG,可改善缺氧动物的氧分压和血氧饱和度。

英文摘要:

Microcirculatory flow of nail bed,blood-2,3 DPG and deformability of RBC in 40 cases with different degree 9f CHD were studied and found that:（1）velocity of flow was inversely proportional to vessels involved（P<0.01）;（2）Salvia miltiorrhiza（SM）increased velocity of flow,with its action delayed in proportion to vessels involved;（3）2;3 DPG of RBC and blood were increased after SM administration;（4）deformability and filtration of RBC were increased after SM administration（P< 0.01）.In 12 rabbits,20% dextrane was given to form acute microcirculatory disturbance model. Mesenteric microcirculatory flow,blood 2,3 DPG,and deformability and filtration time of RBC were studied before and after dextrane and SM administration.It was found that:（1）velocity of blood flow was slowed after dextrane and increased after SM（P<0.01）;（2）blood and RBC 2,3 DPG were decreased after dextrane and increased by SM（P<0.01）;（3）deformability and filtration time were decreased after dextrane and increased after SM（P<0.01）.The blood gases and 2,3 DPG of 12 rats were studied after putting into an airtight bottle containing 12～15% O₂ for 30 min.to form acute hypoxia model.It was found that PO₂ and 2,3 DPG were lowered in control and only slightly lowered in SM group（P<0.01）.It was concluded that there was microcirculatory and 2,3 DPG disturbance in patients with CHD whichcould be improved by SM.The increase of microcirculatory flow after SM was related to increase of 2.3 DPG of RBC and deformability of it.which maintained a relative high PO₂ of blood after an hypoxic condition.

关闭