黄连素治疗Ⅱ型糖尿病60例疗效观察及实验研究

作者	单位
倪艳霞	解放军第208医院
刘安强	解放军第208医院
高云峰	解放军第208医院
王卫红	解放军第208医院
宋亚贵	解放军第208医院
王丽辉	解放军第208医院
张玉华	解放军第208医院

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中文摘要:

本文报告应用黄连素治疗Ⅱ型糖尿病60例的临床疗效及动物实验研究。结果表明黄连素对Ⅱ型糖尿病患者及实验性糖尿病动物均有明显降低血糖效果,患者临床症状基本消失,血清胰岛素水平上升,临床总有效率可达90%,无明显副作用。通过实验动物病理检查胰岛β细胞的观察表明黄连素有促进β细胞修复的作用。

英文摘要:

Since 1983,the authors have observed the therapeutic effect of berberine on 60 cases with type Ⅱ diabetes mellitus.Among these cases the average age of 36 males and 24 females was 54.Of these patients,18 were obese,8 over-weighted and 34 standard weight.Among them,12 patients were severe,38 mediate and 10 mild.Self-comparison was taken.Therapeutic diet of diabetes was prescribed only one month.With the exception of effective cases,berberine was given 0.3～0.5g three times a day by oral administration for 1～3 months. As the result of treatment,major symptoms of diabetes disappeared,the patients’strength enhanced,their blood pressure once complicated with hypertension turned to normal and blood lipid decreased.The fasting glycemic levels in 36 patients were controlled,14 cases turned better,4 cases effective,6 cases ineffective.The total effective rate attained to 90% without serious adverse reaction to berberine during the treatment. In experimental study the authors made close observation on modelled rats suffering from diabetes induced by alloxan and chosen rats of glycemic levels being 16.65～27.75 mmol/L (300～500mg/dL).These animals were divided into berberine group and control group.After a course of the treatment,all animals were dissected and their whole pancreas were taken out to be examined pathologically.The results showed that the animals of berberine group were healthier than those of the control group(P<0.01).It is suggested that the mechanism of declining blood sugar by berberine may be associated with promoting regeneration and functional recovery of pancreas islet β-cells.

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