活血化瘀法治疗硬皮病临床实验观察

作者	单位
苑勰	北京协和医院
李景德	中国医学科学院血液学研究所
朱惠通	中国医学科学院血液学研究所
王荷碧	中国医学科学院血液学研究所
刘杰文	中国医学科学院血液学研究所
钱冠清	中国医学科学院血液学研究所
朱明娟	中国医学科学院血液学研究所

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中文摘要:

本文介绍应用活血化瘀法治疗各型硬皮病725例,分3组用不同的活血化瘀方剂治疗,取得了较好的疗效。1、2、3组系统性硬皮病显效率分别为28.8%、37.2%、40.7%,有效率分别为98.0%、97.7%、96.6%;局限性硬皮病显效率分别为47.6%、46.3。44.9%。临床与实验研究证明活血化瘀药物作用是多方面的,可改善血液循环与结缔组织代谢,特别是对结缔组织有软化作用。

英文摘要:

Of 725 cases of scleroderma,265 were of systemic type(the sex ratio being IM:6F)and 460 of circumscribed type(the sex ratio being 1M:1.9F).The patients were divided into three groups and treated with three different stimulating circulation to end stasis(SCES)prescriptions.Satisfactory therapeutic effects were obtained in all.According to the clinical practice and laboratory findings, although SCES therapy exerted manifold actions on the disease,it not only softened the indurated connective tissues,tonified the body and improved the symptoms,but also improved laboratory indexes as follows:nailfold bed capillary,parameter of the peripheral blood stream in patient, content of urinary 2-ketol,17-KS,free corten,serum joint-hexose,amino-hexose and histopathology including ultrastructure of the skin.The main effect was the improvement of circulation,especially the microcirculation and regulation of the metabolism of the connective tissues.Great attention should be paid to the drug’s function of softening the indurated connected tissues. For further investigation,the authors have stressed three important points:scruting of clinical symptoms and signs,examination of blood circulatory disturbances,and examination of pathological changes of the connective tissue.The necessity of developing new criteria for judging the therapeutic effects was emphasized.

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