新灯盏花素体内抗血栓形成的作用

作者	单位
王兆钺	苏州医学院血栓与止血研究室
陈德春	苏州医学院血栓与止血研究室
何杨	苏州医学院血栓与止血研究室
阮长耿	苏州医学院血栓与止血研究室

摘要点击次数: 1170

全文下载次数: 919

中文摘要:

新灯盏花素是植物灯盏花中一种有抗血小板作用的复盐成分。在家兔的主动脉血栓模型中能减轻血小板的破坏与5-羟色胺释放反应,对血栓形成有明显的抑制作用,这种作用与剂量呈正相关性。新灯盏花素对血小板与血管内皮细胞的花生四烯酸代谢物TXB₂与6-酮-PGE1α的生成均有抑制作用。试验结果表明该药在体内有强烈的抗血栓效应。

英文摘要:

New-Breviscapine is an anti-platelet compound with some kinds of salts extracted from a Chinese herb Erigeron breviscapus.In aortic thrombus formation in rabbits,the platelet 5-HT release reaction and platelet destruction could be reduced by the compound,meanwhile aortic thrombosis was inhibited with a clear correlation between drug dosage and its efficacy.It was shown that new-breviscapine could inhibit the production of TXB₂ and 6-keto-PGF₁ α by platelets and endothelial cells respectively.The data suggest that new-breviscapine has a significant inhibitory effect on thrombus formation in vivo through suppression of platelet functions.

关闭