复方酸枣仁安神胶囊治疗失眠症的疗效观察及药理研究

作者	单位
马有度	重庆医科大学第二附属医院中医科
李荣亨	重庆医科大学第二附属医院中医科
陶元津	重庆医科大学第二附属医院中医科
孙立仁	重庆医科大学第二附属医院中医科
胡光志	重庆医科大学第二附属医院中医科
刘岳风	重庆医科大学第二附属医院中医科
邓文龙	四川省中药研究所药理室

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中文摘要:

对374例失眠患者随机分为复方酸枣仁安神胶囊、朱砂安神丸及安眠酮3组治疗。总有效率分别为84.15%,67.06%及81.61%。结果表明,复方酸枣仁安神胶囊疗效优于朱砂安神丸(P<0.005),而与安眠酮相仿(P>0.05)。睡眠脑电图及动物实验表明,复方酸枣仁安神胶囊疗效可靠,作用迅速,安全无毒。

英文摘要:

374 patients suffering from insomnia were divided into three groups by random:202 cases in group Ⅰ were treated with compound Suanzaoren Ansen capsules（SAC）;85 cases in group Ⅱ were treated with Zhusha Ansen（硃砂安神）pills（ZAP）as control;87 cases in group Ⅲ were treated with Methaqualone（Hyminal）also as control.The therapeutic results were as follows:Groups Ⅰ,Ⅱ and Ⅲ snowed significant effective rates of 49.50%,18.82% and 32.18% respectively;moderate effective rates of 34.65%,48.24% and 49.43% respectively;and total rates of effectiveness of 84.15,67.06% and 81.61% respectively.The authors found significant statistical difference between group Ⅰ and Ⅱ（P< 0.005）and of no statistical difference between group Ⅰ and Ⅲ（P>0.05）.The results showed that the effects of compound SAC were better than ZAP,and similar to that of methaqualone.EEG analysis carried out while sleeping confirmed the effects mentioned above.Low toxicity(LD₅₀10.7 g/kg)of compound SAC was found through animal experimentations.No towards reactions were revealed in clinical trials except nausea in 3 cases.Heart rate and blood pressure changed lightly in a few cases.

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