助阳中药对正常大鼠甲状腺激素代谢的影响及进退法用药的探索

Influence of Yang(阳)-Restoring Herb Medicines upon Metabolism of Thyroid Hormone in Normal Rats and an Approach of Forward-Backward Medication Method

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中文关键词: 甲状腺激素进退法助阳药正常大鼠中药代谢大剂量动物大鼠血清不利影响

英文关键词:

基金项目:

作者	单位
陈名道	上海市内分泌研究所
邝安堃	上海市内分泌研究所
陈家伦	上海市内分泌研究所
唐金凤	上海市内分泌研究所
李凤英	上海市内分泌研究所
陈淑菁	上海市内分泌研究所
陈梦月	上海市内分泌研究所

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中文摘要:

较大剂量的助阳益气中药党参、黄芪、仙灵脾、附子、肉桂、肉苁蓉对正常大鼠有不利影响:自然增重减慢（P<0.01）,血清 T₃下降（P<0.05）,rT₃及 TRH 升高（P<0.01）,TSH 有上升趋势。这些变化可能是中药影响甲状腺激素外周代谢的结果。可用进退给药法加以避免。提出:无虚之机体一般不宜用大量助阳药,若要用可试用进退,法。

英文摘要:

Large dose of Yang（阳）-restoring herb medicines（Radix Codonopsis Pilosulae,Astragalus membranaceus,Radix Aconiti Praeparata,Epimedium brevicornum,Cortex Cinnamomi and Herba Cistanchis）may exert an unfavorable effect on normal rats,i.e:natural weight gain reduced（P< 0.01）,serum T₃ decreased（P<0.05）,rT₃,TRH levels raised（P<0.01）and TSH showed a raising tendency.Lower T₃ and higher rT₃ levels may be the effects of Yang-restoring herb medicines on the peripheral metabolism of thyroid hormones,i.e.more thyroxine was degraded to rT₃ with little biological effect and less was transformed to T₃ with strong hormonal effect.This unfavorable effect,however,can be avoided by Forward-Backward method.It was advised that large dose of Yang-restoring herb medicines could not be given to the organisms without symptoms of Yang deficiency.If it were tried to do so,Forward.Backward method might be recommended.

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