冠脉乐治疗冠心病的临床研究

作者	单位
林求诚	福建省中医药研究所临床研究室厦门市医药研究所临床研究室山东省海洋药物科学研究所临床药理研究室

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中文摘要:

本文报告用冠脉乐片治疗270例冠心病的临床研究,心绞痛症状疗效显效率36%,总有效率80%;心电图疗效显效率15%,总有效率53%。它的疗效与潘生丁、活血丹、复方丹参等比较差异无显著性。根据临床结合实验室若干指标的观察,提示冠脉乐有抗心肌缺血、调节心率、抗异位心律,改善心功能、改善血液流变状态等作用。

英文摘要:

After finding that Fomitiporia Runctata Murr had been used to treat angina pectoris as a folk remedy,medical workers of Fujian Samming Fongous Institute engaged in the separation and identification of flora,and made out sugar-coated tablets of GML.This article reports clinical observation of tablets of GML treating 270 cases of CHD.Among the control group,31 cases were treated by Persantine,20 cases by Huo Xin Dan(活心丹),30 cases by compound Salviae milliorrhizae. Among 222 cases of angina pectoris,80 cases acquired evident effect(36%),98 cases acquired improvement(44%),42 cases failed to respond to the treatment(19%)and 2 cases became worse (1%).Total effective cases were 178 and total effective rate was 80%.There were 250 cases who had ECG evaluation:37 cases-acquired evident effect(15%),95 cases showed improvement(38%),116 cases had no change(46%)and 2 cases became worse(1%).Total effective cases were 132 and total effective rate was 53%.There was no significant difference between the effect of tablets of GML and that of Persantine,Huo Xin Dan and compound Salviae rniltiorrhizae.According to the clinical laboratory observation,there were many functions of GML,such as antimyocardial iscbemia, regulating heart rate,antiectopic cardiac rhythm and improving cardiac function and disorder in hemorrheology.The authors also used GML to treat 90 cases of arrhythmia.It was effective in 50 cases,and total effective rate was 56%.The effect was relatively good in treating atrial premature beat.Perhaps the characteristic of GML was that it could be used to treat angina pectoris as well as arrhythmia.There was only little side effect in GML:some patients complained of thirst,stomach discomfort,abdominal distension and constipation.There was no harmful effect to heart,liver, kindey and blood.

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