参芪注射液对气虚证小鼠免疫反应影响的实验研究

作者	单位
周勇	北京中医学院免疫研究室
严宣佐	北京中医学院免疫研究室
徐音	北京中医学院免疫研究室
陶君悌	北京中医学院免疫研究室
张丽	北京中医学院免疫研究室
顾立刚	北京中医学院免疫研究室
刘宏阳	北京中医学院免疫研究室

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中文摘要:

按照中医"饥则损气"理论,通过控制动物饲料量造成"气虚证"动物模型。与正常组小鼠相比,气虚组小鼠体重、胸腺指数、脾指数、细胞免疫(DTH)和体液免疫(PFC、HA)反应均有明显降低。同时发现参芪注射液对正常动物及"气虚证"动物的体重及正常小鼠脾指数无明显影响,其它指标均有明显的升高。但正常动物不如虚证动物升高明显。以 SRBC4×10~9/只腹腔注射给正常供体小鼠进行超剂量免疫,能明显诱导 Ts 细胞产生,而参芪注射液能降低这种诱导的 Ts 细胞产生。本文论证了中医"气"与机体免疫反应的内在联系,证明了参芪注射液通过降低 Ts 细胞而起免疫促进作用。

英文摘要:

According to TCM theory"hunger impairs one’s Qi(气)",the authors had made mouse model of Qi deficiency syndrome(QDS)through controlling amount of food fed.Compared with mice of normal group,the body weight,thymus index and spleen index obviously decreased in mice of QDS group.The similar effects on humoral immunity and cell-mediated immunity were also obtained.It was found that the Codonopsis pilosulae and Astragalus Injection(CPAI)possessed the promoting action of thymus index,spleen index,humoral immunity and cell mediated immunity on QDS mice and normal mice except spleen index.However,QDS mice were more sensitive to CPAI than the normal mice.4×10~9 SRBC/mouse was administered to normal donor mice by i.p.,the super-optimal immunization could obviously induce generation of Ts cells.The CPAI could also reduce generation of Ts cells.This paper had proved that the inherent relation between Qi and immune response of organism,and that the CPAI could promote immune response by means of reducing Ts cells.

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