复方金钱草膏防治胆石病的临床和实验研究

作者	单位
张广生	中国中医研究院西苑医院外科
李世忠	中国中医研究院西苑医院外科
徐萃华	中国中医研究院西苑医院外科
傅贤波	中国中医研究院西苑医院外科
赵晋宁	中国中医研究院西苑医院外科

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中文摘要:

采用复方金钱草膏治疗胆石病120例,结果治愈29例(24.2%),显效42例(35.0%),好转40例(33.3%),无效9例(7.5%),总有效率92.5%。实验研究表明复方金钱草膏有预防胆石形成的作用。

英文摘要:

This paper reports the clinical treatment of 120 patients with cholilithiasis for 2 months With Jinqiancao Gao.The Results showed that the clinical effective rate was 92.5%,among which 29 cases were cured,42 cases markedly improved and 40 cases ineffective.Animal experiments showed that this medicine can prevent gallstone growth.The gallstone growth rate was 78.5% in the control group and 42.8% in the experimental group(P<0.05).The mechanism of the decrease of gallstone growth rate suggests that the said medicine could inhibit the activity of β-Glucuronidase in the bile, diminish the non-combined bilirubin and prevent the bile from forming bilirubin stones. The result of cultured liver cells in vitro showed that the cholesterol synthesis was markedly inhibited by Jinqiancao Gao.Thus the cholesterol concentration of bile was decreased.These effects in turn prevented the bile from forming cholesterol stones.

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