雷公藤流浸膏片治疗红斑狼疮的疗效观察

用雷公藤流浸膏片治疗23例红斑狼疮患者,并与同期仅用强的松治疗的19例系统性红斑狼疮(SLE)患者作对照。结果15例 SLE 患者症状得到控制,雷公藤组9/15例,对照组6/19例(P>0.10);消除关节痛,雷公藤组7/10例,对照组7/15例;消除盘状红斑,雷公藤组6/8例,对照组5/12例。8例盘状红斑狼疮(DLE)患者仅用雷公藤治疗,4例病情控制好转。雷公藤的副作用有外周血白细胞数下降,个别病例出现蛋白尿,表明雷公藤毒性作用与治疗有效量很接近,应用时应慎重,尤其对有肾脏损害的患者应注意。目前用雷公藤的适应症以 DLE 及无肾脏损害的 SLE 为宜。

英文摘要:

Twenty-three cases of lupus erythematosus,including 15 cases of SLE and 8 casas of DLE treated with Tripterygium wilfordii(TW,three tablets thrice a day,each tablet contains 5 gm of crude TW)were reported.As controls,19 cases of SLE were treated with prednisone alone at the same time.9/15 cases in the former group and 6/19 in the latter got improvement after treatment. There was no significant difference between the two groups(P>0.10).However,TW had beneficial effects to remission of arthralgia(7/10 in the former group and 7/15 in the latter group)and erythematosus rash(6/8 in the former group and 5/12 in the latter).Clinically,four out of eight cases of DLE improved after treatment with TW.TW had some toxic effects,such as decrease of peripheral blood leukocyte and kidney damage.Since the toxic dose and effective dose could be quite close,special attention should be paid when the drug was being used,especially on those patients with nephropathy.So the authors suggested that the indication of TW could include the patients of DLE and SLE without nephropathy.

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