肾虚患者的自然杀伤细胞活性研究

我们用⁵¹铬释放法检测了61例肾虚患者外周血 NK 细胞活性,发现肾虚患者的 NK 细胞活性明显低于健康人（P<0.001）;且肾阳虚组低于肾气虚组（P<0.01）和肾阴虚组（P<0.01）,而肾气虚组与肾阴虚组对比 P>0.05。结果表明 NK 细胞活性低下是多病种肾虚的共同表现之一。同时还发现43例肾虚患者的血浆能强烈抑制健康人的NK 细胞活性,说明肾虚患者血浆中存在某些能强烈抑制 NK 细胞活性的物质。提示我们应进一步研究中医肾与 NK 细胞的关系及补肾治疗对 NK 细胞活性的增强和调节作用。

英文摘要:

Natural killer cell(NKC)plays an important role in anti.cancer,anti-virus and the regulation of immune reaction in human body.NK cell activities from the peripheral blood were determined with (51)~Cr release method from the human erythroleukemia cell line K562 in61 patients,who were selected in the light of the standard of deficiency syndrome in TCM with insufficiency of the Kidney in which 12 kinds of diseases in western medicine were included,and 60 healthy subjects as control group.The patients with insufficiency of the Kidney showed significantly decrease in NK cell activity compared to the control group(25.29±10.20 vs 56.27±16.72,P<0.001).NK cell activities in 20 out of 60 patients, with deficiency of Kidney-Yang(阳),were lower than 21 with deficiency or Kidney-Yin(阴)(19.38± 7.44 vs 26.60±8:95,P<0.01)and 20 with deficiency of Kidney-Qi(气)(19.38±7.44 vs 29.38±11.30,P< 0.01),respectively,while there was no difference between the deficiency of Kidney-Qi(P>0.05).The_ authors also found that NK cell activities of healthy subjects were strongly inhibited by plasma from 43 out of 61 patients.These results suggested that decreased NK cell activity is one of the common characters in patients with insufficiency of the Kidney in TCM and there are some inhibitory substances against NK cell activity in plasma of ones.The fact that NK cell activity of patients with deficiency of Kidney-Yang was the lowest among three kinds patients with insufficiency of the Kidney.It supports the theory of Kidney-Yang playing much more important part in human body. It was proposed that the relationship of NK cell and the Kidney in TCM and the increase and regulation of NK cell activity with tonifying Kidney should be further studied.

关闭