逐瘀温宫汤治疗血瘀挟寒型功能性痛经临床及实验研究

作者	单位
吴锐	成都军区总医院中医科
韩天佑	陕西中医学院
姜伟君	陕西中医学院
张文阁	陕西中医学院
马桂文	陕西中医学院
薛振芳	陕西中药研究所药理室

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中文摘要:

采用逐瘀温宫汤治疗血瘀挟寒型功能性痛经66例,结果痊愈47例,好转13例,总有效率90.9%。治前盆腔血流图提示盆腔血液循环欠佳,与正常组比较有显著性差异;治疗1疗程后有明显改善,与正常组比较无显著性差异,与治前比有显著性差异。实验研究表明,本方对兔在体子宫、大白鼠离体子宫的自发活动及15-甲基前列腺素F2α所致的子宫活动增强,均有抑制作用,并可改善兔痉挛的子宫血流。对大白鼠痛经模型也有镇痛作用。

英文摘要:

Sixty-six women with stagnant blood and cold dysmenorrhea were treated with Zhuyu Wengong Decoction(ZWD).The results showed that 47 of them were cured,13 improved,the total effective rate was 90.9%.Before treatment,the value of amplitute and the volume of blood flow in the left pelvic cavity with blood flow graph was very lower in the dyamenorrhea patients than those in the normal women(P<0.01),while the number of amplitute difference between the left and the right pelvic cavity being over 30% and of abnormal wave was higher in the patients than that in the normal women(P<0.01).After treatment,the value of amplitute and the volume of blood flow in the left,pelvic cavity had a marked increase(P<0.01).These data suggested that blood circulation in the pelvic cavity took a turn for the better after the treatment. The results in animal experiment also showed that ZWD had strongly suppressive effect on the automatic action of uterine muscle of rats in vitro and of rabbits in vivo.The suppressive rates were 30.75% and 20% respectively,and the contractive range was at a lower level.The decoction also had strong suppressive effect on the contract induced by MPGF2α,suppressive rate decreased to 24.4% and 34.75% respectively in contrast to the group which patients had not taken this decoction.The results in this study also proved that ZWD could improve the reduction of blood flow volume induced by MPGF2α and had analgesic effect on dysmenorrhea model of rats induced by oxytocin.

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