| 徐乐凤,王曼,赵承洛.醋酸棉酚治疗子宫内膜异位症临床及实验研究[J].中国中西医结合杂志,1989,(8):462-464,451 |
| 醋酸棉酚治疗子宫内膜异位症临床及实验研究 |
| Clinical Effects and Experimental Study on Gossypol in Endometriosis |
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| DOI： |
| 中文关键词: 子宫内膜异位症 醋酸棉酚 异位子宫内膜 子宫内膜组织 组织化学 垂体促性腺激素 血清孕酮 激素依赖性 治疗后 雌二醇 |
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| 中文摘要: |
| 子宫内膜异位症患者接受醋酸棉酚治疗后,临床症状明显改善,病灶包块缩小,基础体温转为单相。血清孕酮,雌二醇水平下降,而垂体促性腺激素(FSH、LH)则明显上升(P<0.01)。组织化学及细胞化学观察发现在位及异位子宫内膜中雌、孕激素依赖性酶——酸性磷酸酶(ACP)、非特异性脂酶(NSE)、碱性磷酸酶(AKP)活性均下降。结果提示:醋酸棉酚对子宫内膜有直接的和间接的作用。并对其作用机理进行了探讨。 |
| 英文摘要: |
| Effects of the gossypol on endometriosis in 12 cases of control were observed.The results showed that the gossypol administered orally was effective in endometriosis patients.The basal body temperature changed from biophase to monophase.Dysmenorrhea disappeared in 11/12 patients.Ameaorrhea occurred in 10/12 patients and the ovarian endometrial cyst was shrinkable. Serum progesterone and estradiol were decreased after gossypol administration,but follicle- stimulating bormone and luteinizing hormone were increased evidently.Histochemical and cyto- chemical observations revealed that the activity of acid phosphate(ACP),nonspecific esterase(NSE) and alkaline phosphate(AKP)in both aberrant uterine endoraetrium and uterine endometrium in situ were decreased evidently.The above results suggest that the satisfactory therapeutic efffect of gossypol on endometriosis may be due to not only the indirect but also the direct action on uterine endometrium. |
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