溃疡性结肠炎中草药治疗及某些免疫功能动态观察

作者	单位
郭琪	西安医科大学第一附属医院中医教研室
万素清	西安医科大学第一附属医院中医教研室
郭珍	西安医科大学克山病研究室
张培毅	西安医科大学克山病研究室

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中文摘要:

本文观察对比了用中草药制成的"消溃汤Ⅰ、Ⅱ号"灌肠和肠溶胶囊口服治疗260例溃疡性结肠炎(UC)的疗效,异对28例 UC 患者在治疗前后检测了免疫复合物和自身抗体的动力学变化。结果发现:(1)灌肠组和口服组的总有效率无明显差异(93.3%和87.5%),但灌肠组对脓血便、粘液便以及糜烂合并溃疡病变的治愈率明显高于腱囊组(P<0.01)。循环免疫复合物在28例 UC 患者43例次中,超过正常值上限者21例次,阳性率为48%,在28例中17例阳性,阳性率60.7%,且在治疗后随着病情好转有下降趋势;UC 患者的抗核抗体用间接荧光免疫法和间接免疫酶标法检测,阳性率分别为53.6%和64.7%,均高于对照组(P<0.01)。

英文摘要:

The effect of the traditional Chinese medicinal herbs enema and enteric-coated capsules in the treatment of ulcerative colitis(UC)were compared in 260 cases.The immune complexes and the dynamic change of autoantibodies were monitored in 28 out of the 260 cases before and after treatment.The following results were observed.(1)There was no significant difference in the total effective rate between the enema group and the oral capsule group(93.3% and 87.5% respectively), but the recovery rates of purulent hemafecia,mucusfecia and erosion accompanying colitis,etc.in the former group were higher than those in the latter(P<0.01).(2)The circulating immune complex- es were found 43 times above the normal range in 17 cases with positive rate 60.7% and tended to decrease as the condition became better after treatment.Antinuclear anttbodtes were determined by the indirect fluorescent immune method and the indirect enzyme labelling method and the positive rates were 53.6% and 64.7% respectively,both being much highter than those in the controls(P<0.01).

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