气血注射液对窦房结起搏细胞自律活动的调整作用

本研究用微电极技术观察了由人参、黄芪和当归组成的气血注射液对窦房结起搏细胞电活动的影响。气血注射液对窦房结细胞的活动有负性频率效应。其主要作用环节是降低舒张期自动去极化速率和延长舒张期自动去极化时程。气血注射液还共有使低氧合并41℃高温或合并异丙肾上腺素作用下引起的节律过缓,不齐转为节律整齐、自律频率加快的作用。结果说明气血注射液对窦房结的节律活动具有双相的调节作用。

英文摘要:

This study investigated,with microelectrode technic,the effects of electrical activities in pacemaker cells of sinoatrial node by Qixue injection consisting of Ginseng,Astragali and Angelicae sinensis,which may replenish the Qi(气)and invigorate the circulation of blood.Qixue injection produced a negative chronotropic action on beating of sinoatrialnode mainly because of lowering the rate of diastolic automatic depolarization andlengthening the duration of diastolic depolarization as well,but this action was caused through neither cholinergic M receptors nor adrenergic β receptors. With hypoxia at temperature of 41℃ or with isoprenaline in existence to cause beating slowness and arrhythmia,Qixue injection turned them into rhythmical beating and quickened automatic beating frequency.It suggested that Qixue injection could-antagonize pathologic changes caused by insuffi- ciency of oxygen supply and improve function of sinoatrial node.Also it indicated that Qixue injection had a biphasic function on regulating rhythmical activities of sinoatrial node,which might be one of the mechanisms of the drug used clinically.

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