益气活血法治疗慢性非特异性结肠炎的临床及实验研究

用益气活血法同疗效较为肯定的健脾益气、清热祛湿法对照治疗了30例慢性非特异性(溃疡性)结肠炎患者,并检查了其治疗前后的体外血栓和血栓弹力图的情况。在此基础上,进一步研究了上述两法对溃疡性结肠炎大鼠模型的影响。结果发现本病存在血液离凝状态,并与结肠炎症损伤程度呈正相关性;两法的治疗效果基本相似,充分肯定了益气活血法治疗本病的作用。

英文摘要:

Yiqi Huoxue principle(YH)was applied to treat 30 cases of ulcerative colitis while Yiqi Jianpi (益气健脾)and Qingre Qushi(,清热祛湿)principle(YJQQ),which had been proved its therapeutic effect,was used as the control therapy.The herhal medicines were taken by oral and enema.The course of treatment was 6 weeks.The length,wet and dry weights of thrombus,the platelet adherence and the r,k,Ma,M values of thrombelastogram were measured before and after medications.Before medication,the value mentioned above were all abnormal in both YH and YJQQ group.After medication,with alleviationof the symptoms and signs of the colitis,all these values trended gradually to normal levels(P<0.01).The rat models of ulcerative colitis were made by immunological and local stimulation methods.The models were divided into three groups:YH(Ⅰ), YJQQ(Ⅱ)and water group(Ⅲ).Three weeks after medication,the results showed that the lesion degree of the colon,the length and weight both wet and dry thrombus were remarkably lower in group Ⅰ than those in group Ⅲ.It was also showed that there was a positive correlation between the lesion degree of colon and the dry weight of thrombus(r=0.7941,P<0.01).It suggested that the therapeutic effects of YH was similar to those of YJQQ in treating ulcerative colitis.

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