冠心病患者血小板膜糖蛋白及血小板功能与中医辨证分型关系的研究

作者	单位
贾宝善	黑龙江中学医学院附属医院
刘莉	黑龙江中学医学院附属医院
马军	哈尔滨市第一医院
余袭南	哈尔滨市第一医院

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中文摘要:

应用抗人血小板膜糖蛋白(GPIb)单克隆抗体 SZ-2,对56例冠心病患者血小板 GPIb 进行免疫荧光定量分析,并观察血瘀证及非血瘀证患者的血小板 GPIb 变化,同时测定血小板粘附性(PAdT)及血小板聚集性(PAgT)。结果表明:冠心病患者血小板GPIb 水平增高,其中以急性心肌梗塞(AMI)组最明显(P<0.01),其次为不稳定型心绞痛(UA)、稳定型心绞痛(SA)组。患者 PAdT、PAgT 水平也显著高于对照组(P<0.005、P<0.05);血小板 GPIb、PAdT、PAgT 水平血瘀证组显著高于非血瘀证组及对照组(P<0.001),提示血小板 GPIb 异常增高是冠心病血瘀证发生的病机之一。

英文摘要:

This experiment made quantitative analysis of platelet GPlb of 56 patients with coronary heart disease and with McAb SZ-2 resisting to human being platelet GP by using the method of indirect immunity fluorescence saturation,observed the changes of coronary heart patients’platelet GPlb based on TCM differentiation of the pattern,and determined the level of PAdT,PAgT.The results showed that the level of platelet GPlb of coronary heart disease was higher than normal.Among them,the acute myocardiac infarction group was the most obvious,followed by the unstable angina pectoris group and the stable angina pectoris group.The level of PAdT,PAgT of coronary heart patients was higher than those of the normal group(P<0.005,0.05);the level of platelet GPlb in blood stasis syndrome group was higher remarkably than the group of having no blood stasis syndrome and the normal(P<0.001).These results suggested that it played an important part in the occurrence and development of coronary heart disease as manifested by abnormal increase of ptatelet GPlb,and enhancement of platelet’s adherence and aggregation.The abnormal increase of platelet GPlb is due to pathological mechanism of blood stasis syndrome of coronary heart disease.This experiment also provided a fresh evidence to TCM differentiation of the pattern and treatment of coronary heart disease.

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