助阳中药对正常雄性大鼠肾上腺皮质、睾丸及甲状腺激素浓度的影响

作者	单位
邝安堃	上海第二医科大学上海市内分泌研究所
陈家伦	上海第二医科大学上海市内分泌研究所
陈名道	上海第二医科大学上海市内分泌研究所
李凤英	上海第二医科大学上海市内分泌研究所
唐金凤	上海第二医科大学上海市内分泌研究所
张美云	上海第二医科大学上海市内分泌研究所
金静芬	上海第二医科大学上海市内分泌研究所
陈梦月	上海第二医科大学上海市内分泌研究所

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中文摘要:

本文报道了附子肉桂、仙灵脾、肉苁蓉4药单独及联合应用对正常雄性大鼠血皮质酮（B）、睾酮（T）及三碘甲腺原氨酸（T₃）浓度的影响。4药均有提高 B 的作用,以肉苁蓉最为显著（P<0.001）;肉桂升高 T（P<0.05）;但附子、肉桂使 T₃下降（P<0.01及 P<0.05）,附子使 T₃显著降低,可能为机体对附子的毒性的适应性保护机制。4药联合应用并不是4药作用的叠加,而是基本上反映了4药的平均作用,其中可能有相互制约的机制。

英文摘要:

It had been found that Yang-restoring herb medicines Radix Aconiti Praeparata（AP）,Cortex Cinamomi（CC）,Herba Cistanchis（HC）and Epimedium brevicorum（EB）reduced the cold-resistant potential of normal mice and disturbed the balance of thyroid hormones in normal rats.The aim of this study was to further investigate the effects of these four herb medicines on the levels of plasma corticosterone（B）,testosterone（T）and triidothyronine（T₃）in rats by administering herbs together （mixed group）or individually. It was shown that all four Yang-restoring herbs tended to raise plasma B level and it was significant in HC,EB and mixed groups,especially in HC administered rats（P<0.001）.Rise of plasma T level was seen in CC and mixed groups.All four herbs could decrease plasma T₃ level and it was significant in AP,CC and mixed groups,particularly evident in AP administered rats（P<0. 001）.This may be one of the adaptating-protecting mechanisms of normal organism against the toxicity of AP.Combination of the four herb medicines did not result in the cumulation of effects of the given medicines,however,this did reflect the average effect of these four herbs,which showed a restraining and harmonious relationship in a Chinese medical prescription.

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