腹部手术后和重症急腹症患者胃阴虚证研究(Ⅰ)

为探讨胃阴虚证病理本质,我们选择了腹部手术后和重症急腹症胃阴虚证患者为观察对象,测定了血浆内毒素含量,机体免疫功能,血液流变学,舌的温度、表面pH 值、电导指数和舌血液灌注率等指标。结果显示,胃阴虚证患者血浆内毒素的含量都高于正常,表现为不同程度的内毒素血症;细胞免疫功能受损,出现了异常免疫病理反应;体液免疫功能和补体系统无明显损害;舌的温度、表面 pH 值和舌表面电导指数下降;舌血液灌注率减少:血浆粘度增加、血沉加快、血中纤维蛋白原浓度上升。以上结果可以从不同角度反映胃阴虚证的部分病理状态。

英文摘要:

The Spleen-Stomach theory is an important component of the theories of TCM.Exploration of pathophysiologic changes in patients with Stomach Yin Deficiency Syndrome（SYDS）is of help in explaining the Spleen-Stomach theory.Hence patients with SYDS due to abdominal operation or severe acute abdominal diseases were selected as objects to be observed.The endotoxin in plasma, immune function of the body,the mean temperature and blood perfusion rate at the centre of the tongue,area representing the Spleen and Stomach,the surface pH and index of electric conduction of the tongue and rheologic changes were determined.The results showed that the content of plasma endotoxin in patients with SYDS was 346±216 ng/ml（（?）±SD）.The value in all patients with SYDS was beyond normal（50 ng/ml）,the highest being 1050 ng/ml.ANAE and LTT were decreased,as compared to the control（P<0.001）.The content of IgG,IgA,CIC in blood increased（P<0.05,P<0. 001,and P<0.001 respectively）,and that of IgM decreased（P<0.002）.The consistency of C₃ in patients with SYDS was 83.6% of the control（P<0.001）,and that of C₄ and C₅ increased（P<0.01 and P<0.001 respectively）.The mean temperature of the tongue with SYDS was 0.64℃ lower than the control（P<0.05）,and the blood perfusion rate was decreased 16.4% than the control（P<0.05）.The surface pH and index of eiectric conduction in SYDS were lower than those in the control（P<0.01 and P<0.001 respectively）.The ESR,plasma viscosity and fibrinogen levels were also increased（P< 0.001）. Judging from the results in this study that there were endotoxemia,lowered cellular immune function,decreased mean temperature and blood perfusion rate of tongue arid rheologic changes in patients with SYDS.the authors are able to infer that cause of SYDS might include infectious endotoxemia and damage of immune function of the body.There were decreased metabolism,blood perfusion rate of digestive tract,damaged secretory and absorptive function and shortage of water and electrolytes in patients with SYDS.

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