葛根素抗冠心病心绞痛疗效观察及对血栓素 A<sub>2</sub>和前列环素的影响

作者	单位
杨国君	白求恩医科大学第二临床学院心血管内科
张龙生	白求恩医科大学第二临床学院心血管内科
范礼理	中国医科院药研所

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中文摘要:

对30例冠心病心绞痛患者用葛根索治疗,同时测定治疗前血浆血栓素 B₂（血栓素 A₂-稳定代谢产物）、血脂、6-酮-PGF_1a（前列环素-稳定代谢产物）及高密度脂蛋白（HDL）的变化,结果表明葛根素除能明显缓解心绞痛、改善缺血心电图、降低心肌耗氧量外,尚能提高患者血浆6-K-PGF_1a及 HDL 水平,同时降低 TXB₂/6-K-PGF_1a比值。

英文摘要:

Plasma concentrations of thromboxane B₂（TXB₂） and 6-keto-prostaglandin Flα（6-K-PGFlα）,the stable nonenzymatic metabolites of TXA₂ and prostacyclin were assayed in 30 patients suffering from angina pectoris before and after administration of puerarin.In addition,serum lipids and HDL were also measured at the same time.20 healthy subjects were chosen as the control group.Two weeks before and during administration of puerarin,aspirin,calcium-antagonists,all kinds of hypotensors and drugs relieving chest pain of angina pectoris were strictly prohibited.Puerarin was intravenously given,500 mg daily for 7 days,which was considered as a therapeutic course.Besides relieving of chest pain,decreasing of heart rate and reduction of blood pressure clinically,it was also found that plasma 6-K-PGFlα concentrations were significantly elevated from 38.32±15.40 to 158. 79±98.62 pg （P<0.01） after administration of puerarin,but there was no significantly difference between plasma TXB₂ concentrations before and after administering the drug.In addition,serum HDL was apparanfly enhanced as compared with that before the administration of puerarin （P<0. 01）.The results indicated that puerarin has the function of anti-angina,reducing both systolic and diastolic blood pressure and diminishing myocardial oxygen consumption.

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