胃宁冲剂治疗慢性浅表性胃炎的临床及实验研究

作者	单位
高寿征	北京积水潭医院
吴文静	北京积水潭医院
王继侠	北京积水潭医院
金树稹	北京积水潭医院
齐玉生	北京市第六医院
张亚琴	北京永定路医院
刘耀祥	北京临床药学研究所
郝仙娣	北京临床药学研究所
龙裕能	北京临床药学研究所
曹霞	北京临床药学研究所
周时来	北京同仁堂制药厂

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中文摘要:

用中药胃宁冲剂对经纤维胃镜及病理证实为慢性浅表性胃炎408例患者进行临床观察,症状有效率为90.5%,胃镜有效率为81.9%,病理有效率为72.8%,与对照组相比有显著差异。动物实验表明胃宁冲剂对实验性胃炎和胃溃疡均有明显的保护胃粘膜作用,其保护作用与甲氰咪胍相似,而明显优于胃舒平。其保护作用不是减少胃酸,而是降低胃蛋白酶的活性。急性和亚急性毒性实验表明胃宁冲剂无毒性,临床患者用药十分安全。

英文摘要:

408 cases of chronic superficial gastritis diagnosed by fibrogastroscopy and histology were treated with Wei-Nin granules（WNG）,The sympatomatic effective rate was 90.5%,while therapeu- tic effect proved by gastroscopy and histology was 81.9% and 72.8% respectively.These results compared with the control were statistically significant.In animal experiment,it is shown that WNG had an evident protective effect to the mucous membrane of rats and guinea pigs.These animals had suffered gastritis and gastric ulcer induced by drugs.The effect of WNG was similar to cimetidin. The pharmaceutical mechanism of WNG proved that it could inhibit the secretion of pepsin.The acute and chronic poisoning test was negative both in vitro and in vivo.WNG were nearly no any side effects in this study.Therefore it is a new type of herbs in treatment of chronic superficial gastritis and is different from H₂-receptor inhibitor.

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