活血化瘀中药对肾病综合征患者高凝指标的影响

作者	单位
吴倾众	上海医科大学儿科医院
顾文华	上海医科大学儿科医院
时毓民	上海医科大学儿科医院
郭怡清	上海医科大学儿科医院
李昆玉	上海医科大学儿科医院
蔡德培	上海医科大学儿科医院

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中文摘要:

测定32例肾病综合征患几的血小板聚集试验(PAgT)、血浆因子Ⅷ相关-抗原(ⅧR:Ag)及白陶土部分凝血活酶时间(KPTT)。结果:肾病患儿这些指标明显异常,提示 PAgT、ⅧR:Ag 及 KPTT 可作为反映肾病综合征高凝状态的实验室指标。对24例上述3项指标异常的肾病患儿运用活血化瘀治疗后,PAgT 及ⅧR:Ag 有改善,提示活血化瘀中药对肾病高凝状态有改善作用。

英文摘要:

Platelet aggregation test (PAgT),plasma factor Ⅷ related antigen (Ⅷ R:Ag) and kaolin partial thromboplastic time (KPTT) in 32 nephrotic children were determinded.Results:(1) PAgT induced by ADP and adrenaline which included 1 minute and 5 minute aggregation rate in the patients (30. 78±7.44%,72.56±18.09%,22.16±9.24%,67.53±22.32%) was significantly increased (P<0.02～0.001) as compared with the normal control group (30.65±8.38%,57.98±13.60%,18.14±7.33%,55.92±16. 10%) except 1 minute aggregation rate induced by ADP (P>0.05).(2)Ⅷ R:Ag and KPTT in patients (226.97±50.47%,32.04±5.88 sec) were obviously different (P<0.001,P<0.02) from the normal control group (107.11±24.55%,35.42±5.00 sec).The results suggested that PAgT,Ⅷ R:Ag and KPTT could be used as laboratory data reflecting the hypercoagulable state in nephrotic children. According to their age,sex and the clinical types of nephrotic syndrome,24 nephrotic children with abnormality of PAgT,Ⅷ R:Ag and KPTT were random divided into group 1 given prednisone only and group 2 given prednisone,blood-activating and stasis removing drugs.Results:the difference of PAgT,Ⅷ R:Ag and KPTT in two groups between pre- and post-treatment was significant statisti- cally (P<0.05～P<0.001).The decline in PAgT and Ⅷ R:Ag was faster in group 2 than in group 1 (P<0.05～P<0.01).The results showed that blood-activating and stasis-removing drugs were likely to improve abnormal PAgT and Ⅷ R:Ag in nephrotic children.

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