六味地黄汤对诱变和自发肿瘤的抑制作用

作者	单位
赵良辅	中国中医研究院中药研究所
严述常	中国中医研究院中药研究所
张玉顺	中国中医研究院中药研究所
李兰芳	中国中医研究院中药研究所
武桂兰	中国中医研究院中药研究所
姜廷良	中国中医研究院中药研究所

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中文摘要:

由小鼠的微核及对自发性肿瘤影响试验,发现六味地黄汤能够降低正常的和化学诱变的动物骨髓多染细胞微核出现率:连续投药60周后,动物肿瘤的自发率随用药剂量增大而降低。其中,大剂量组的自发率明显低于对照组(P<0.01)。说明该方药对突变和癌变皆具有一定的防护作用。

英文摘要:

Anti-mutagenic activity was evaluated with micronuclear test.It appeared to be same between the result of mice treated with 10 g/kg Liuwei Dihuang decoction(LWDHd)for 3 days and that with 34.5 g/kg for 10 days.All the permillages of micronuclear appearance of treated groups were less than that of controls.The intercept(A)value of dose-effect curve were 12.7 and 9.4 as treated with cyclophosphamide(Cy)alone,but 1.2 and 3.2 as orally administered with LWDHd before injecting Cy.It showed that LWDHd could inhibite mutagenic activity of Cy.The affection of LWDHd on spontaneous tumorigenesis was observed in LACA mice.The tumor incidence rate was 9.0% in the control mice observed for 60 weeks,but 5.0% in the animal feeding LWDHd in food.The tumor incidence rate of big dose group was 1.0% and the difference was significant between it and that of the control(P<0.01).

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