心宝丸治疗病态窦房结综合征87例

作者	单位
陈振云	宁波市113医院
田建会	上海市长征医院心内科
杨萍	宁波市113医院
徐正良	宁波市113医院
钱义东	宁波市113医院

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中文摘要:

本文报告用心宝丸治疗病态窦房结综合征87例,结果显示:临床症状改善总有效率85%以上;心功能改善总有效率80%,窦房结恢复时间(SNRT),校正窦房结恢复时间(CSNRT)、心输出量(CO)及射血分数(EF)均显著改善(P<0.01);24h 动态心电图监测平均心率明显提高(P<0.01)。说明心宝丸能改善窦房结功能及心功能、提高基础心率,近期疗效稳定,无明显副作用。但对严重的病态窦房结综合征频繁阿一斯综合征发作者疗效欠佳,仍以安装永久人工心脏起搏器为宜。

英文摘要:

Since 1987,the authors have observed the therapeutic effect of Xin Bao on 87 patients with sick sinus syndrome.Electrophysiological stimulation examination:SNRT>1900 ms and CSNRT>600 ms in all patients.Routine ECG and H olter monitoring ECG:(1)Persistent sinus bradycardia or/and atrio-ventricular junction escape rhythms or/and premature beat,heart rate<48±6 beats/min in 40 patients;(2)sinus standstill (arrest)or secondary degree sinoatrial block in 10 patients;(3) bradycardia-tachycardia syndrome in 30 patients;(4)the heart rate>60 beats/min in 7 patients.The major symptoms were dizziness,palpitation,chest press,malaise,remission in memory,nocturia. amaurosis and Adams-Stokes syndrome,etc.Self-comparison was taken.Xin Bao was given 2～10 tablets 2 or 3 times a day by oral administration for 2 months.The major symptoms of sick sinus syndrome was greatly improved after treatment.The total effective rate attaining to 85%.The improvement in heart function was also significant,the total effective rate being 80%.After treatment SNRT and CSNRT were shortened(P<0.01),the total heart beats for 24 hours and the average heart beats/min greatly increased(P<0.01).CO and EF increased too(P<0.05).No serious adverse reactions were found during the treatment.It was believed that Xin Bao could stimulate sino-atrial node and increase it’s excitability.The basic heart rate was increased and the heart function improved with no adverse reactions.It may be administrated in long term.Therefore,Xin Bao may be recommended as appropriate drug for treating sick sinus syndrome.

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