补肾益气法对淋巴细胞糖皮质激素受体老年性改变的影响

作者	单位
张玲娟	上海医科大学中西医结合研究所
沈自尹	上海医科大学中西医结合研究所
王文健	上海医科大学中西医结合研究所
张新民	上海医科大学中西医结合研究所
陈素珍	上海医科大学中西医结合研究所
陈伟华	上海医科大学中西医结合研究所

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中文摘要:

测定了32名健康老年人和13名健康青年人周围血淋巴细胞糖皮质激素受体(GCR)和血浆皮质醇浓度,同时测定了18只老年大鼠和9只青年大鼠的脾淋巴细胞 GCR,并用补肾益气中药观察其对 GCR 老年性改变的影响。结果表明,GCR 较血皮质醇能更敏感地反映肾上腺皮质功能,老年人及老年鼠的 GCR 均较青年组明显降低,而血皮质醇则无增龄性变化。补肾益气中药能提高老年人及老年大鼠低下的 GCR 水平,藉以改善肾上腺皮质功能。

英文摘要:

The plasma cortisol concentration and the sites of glucocorticoid receptor(GCR)in the periph- eral lymphocytes were measured in 32 healthy aged persons and 13 young adults.In animal experi- ment,GCR of spleen lymphocytic cell was also measured in 18 aged rats and 9 young rats.The results showed that GCR was significantly lower in the aged persons or rats than that in the youngers while the plasma cortisol level didn’t change with aging.So we think that GCR is more sensitive than the plasma cortisol level to reflect the aging change of the adrenocortex function.After the treatment with the regimen of Kidney-tonifying and Qi-invigorating,the GCR of the aged persons and rats was enhanced,and in this way,the function of the aged adrenal cortex was improved.

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