长生降压液对中老年肾虚型高血压病及心肌肥厚影响的临床观察

作者	单位
卫明	安徽中医学院附属医院
陈可冀	中国中医研究院西苑医院老年医学研究所
周文泉	中国中医研究院西苑医院老年医学研究所

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中文摘要:

本文对补肾立法的纯中药制剂长生降压液的临床观察表明,该药可使中老年肾虚型高血压病患者的卧位收缩压.舒张压及平均动脉压明显下降(P<0.001),并能明显缓解高血压病及肾虚症状。同时,该药可使治疗组的左室质量指数由治疗前的114.75±42.40g/m~2减少为治疗12周后的100.39±30.08g/m~2。而对照药罗布麻叶口服液虽亦有降压效果,但未能发现有逆转高血压性左室肥厚的效应。

英文摘要:

A study which enrolled 65 middle-aged and elderly essential hypertensive patients with Kidney- deficiency pattern was carried out to evaluate the effects of Longevity-Antihypertensive-Mixture (LAM).As LAM was composed of Kidney-tonifying herbs,all the subjects chosen fell into the pattern of Kidney-deficiency in TCM,The subjects were randomized into two groups:The LAM group had 34,and the control group taking Apocyhum Venetum L.Fluid (AVLF) 31.The duration of medication was 12 weeks.The main results were as follows:(1)At the end of week 4,the supine systolic blood pressure (SBP),diastolic blood pressure (DBP) and mean blood pressure (MBP) in LAM group declined from 171±16(mmHg,the same below),101±6 and 127±7 to 153±12.93±7 and 113±7 respectively.At the end of week 12,the supine SBP,DBP and MBP were 151±14,93±6 and 112± 8.There was significance of difference in the reduction of supine blood pressure compared with baseline (P<0.001).AVLF produced similar changes in the reduction of supine SBP,DBP and MBP. However,the magnitude of reduction in SBP and MBP was smaller than those with LAM (P<0.001). (2)There was no significance of difference in attaining goal blood pressure between LAM and AVLF groups (P>0.05).At the end of week 4,79.41% and 77.42% were achieved respectively;at 12,79.41% and 80.65%.(3)LAM had stronger effect on relieving symptoms of essential hypertension and Kidney-deficiency than AVLF(P<0.05).(4)In LAM group the left ventricular mass index(VMI) decreased from 114.75±42.40g/m~2 to 100.39±36.08g/m~2(P<0.001).The LVMI in AVLF group increased from 117.27±36.90 g/m~2 to 117.68±38.37 g/m~2(P>0.05).The results supported the thera- peutic principle of TCM:Treating patients according to their pathophysiological patterns.

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