| 张永珍,阎西艴,张延荣,魏太星,党瑜华,彭少良.赤芍和硝苯啶对慢性高脂血症兔血浆TXB2和6-酮-PGF1α的影响[J].中国中西医结合杂志,1990,(11):669-671,645 |
| 赤芍和硝苯啶对慢性高脂血症兔血浆TXB2和6-酮-PGF1α的影响 |
| Effects of Nifedipine and Paeonic lactiflora on Plasma TXB2 and 6-Keto-PGF1α in Cholesterol-fed Rabbits |
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| DOI： |
| 中文关键词: 赤芍 硝苯啶 动脉粥样硬化 钙 过氧化脂质 血栓烷-前列环素平衡 |
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| 中文摘要: |
| 本研究对比观察了赤芍和硝苯啶对兔实验性动脉粥样硬化（AS）的彤响。结果表明,两种药物均使高脂血症引起的 TXA2/PGI2比值改变趋向平衡,降低血浆 LPO、动脉壁脂质、钙和磷脂及主动脉斑块面积。赤芍明显强于硝苯啶。提示两种药物通过影响钙代谢调节 TXA2/PGI2平衡是其抗 AS 主要作用机理之一。赤芍可以作为防治 AS 的一种新药物用于临床。 |
| 英文摘要: |
| The authors examined the influences of nifedipine and Paeonia lactiflora（PL）on plasma LPO, TXB2 and 6-keto-PGF1α in cholesterol-fed rabbits.In this study,oral administration of nifedipine（15 mg/kg per day）and PL（0.5 g/kg per day）with 2% cholesterol diet for 15 weeks caused 60.75% and 74.24% reduction in the lesion area of aorta respectively.The levels of plasma LPO,TXBz, cholesterol,phospholipid and calcium of the intimalmedia of the aorta in the treated groups were significantly lower than those in the control group,but the level of 6-keto-PGF1α in the treated groups was significantly higher.The durations of TXB2 elevation and 6-keto-PGF1α reduction were delayed.The ratio of TXB2/6-keto-PGF1α tended to balance.The ratio of TXB2/6-keto-PGF1α was significantly positive correlation with the percentage of lesion area of the aorta.It is demonstrated that calcium metabolism plays an important role in thromboxane,prostaglandin,and LPO synthesis. In conclusion,the inhibition of LPO production and the regulation of TXA2-PGI2 balance may be one of the mechanisms of anti-atherogenesis of calcium antagonists and PL. |
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