参附柴液与地塞米松对犬感染性休克合并DIC疗效比较

A Comparison Between the Therapeutic Effects of Ginseng-Aconitum-Bupleurum Injection and Dexamethason on Septic Shock Complicated with DIC Induced by E.Coli in Dogs

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中文关键词: 参附柴液休克地塞米松弥漫性血管内凝血

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作者	单位
刘玉英	湖南中医学院活血化瘀研究窒
贺石林	湖南中医学院活血化瘀研究窒
杨锡平	湖南中医学院活血化瘀研究窒
廖希玉	湖南中医学院活血化瘀研究窒
唐荣德	湖南中医学院活血化瘀研究窒

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中文摘要:

本实验观察了参附柴液对犬感染性休克合并 DIC 模型病理生理过程的影响。结果:与盐水对照组比较,中、西药组存活率显著提高(P 分别<0.05、0.01),平均动脉血压(MAP)、血浆纤维蛋白原(FG)降低较慢(P 均分别<0.05、0.01),β-GC 及 AT-Ⅲ改变较小(P 均分别<0.01～0.05)。表明参附柴液能提高存活率,抑制 DIC 发展和稳定细胞膜。

英文摘要:

In this paper,the authors report the theyapeutic effects of Ginseng-Aconitum-Bupleurum(GAB) injection on septic shock complicated with DIC induced by intravenous injection of live E.Coli in dogs.The experimental results indicated that the survival rate at 48 h after intravenous injection of live E.Coli was 30% in saline group,80% in GAB,90% in dexamethasone(Dex)group.The BPC, WBC,FG,AT-Ⅲ,β-GC,PHb were 82±28,9.1±5.9,1.85±0.41,112±43,0.37±0.17,0.11±0.07 respec- tively for GAB,70±37,6.7±3.7,1.55±0.36,59±29,0.91±0.28,0.12±0.06 respectively for the saline group,58±33,6.3±2.9,1.95±0.21,103±43,0.50±0.16,0.13±0.06 respectively for Dex.The BPC, WBC,FG,AT-Ⅲ levels of the GAB group were significantly higher than those in saline group and were not significantly difference from the Dex group.The β-GC and PHh levels of the GAB group were significantly reductive than the saline group and were not significantly different from the Dex group,The results showed that the survival rate was higher,the DIC was inhibited and normal biomembranes were maintained in the GAB group.

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