扶正抗癌方为主结合化疗对158例术后晚期胃癌的治疗及实验研究

Treatment of Operated Late Gastric Carcinoma with Prescription of Strengthening the Patient’s Resistance and Dispelling the Invading Evil in Combination with Chemotherapy:Follow-up Study of 158 Patients and Experimental Study in Animals

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DOI：

中文关键词: 扶正抗癌方化疗晚期胃癌实验研究

英文关键词:

基金项目:

作者	单位
王冠庭	上海第二医科大学附属瑞金医院内科
周玉琴	上海第二医科大学附属瑞金医院内科
鲍绍芳	上海第二医科大学附属瑞金医院内科
张霭梅	上海第二医科大学附属瑞金医院中医科
吴贤益	上海第二医科大学附属瑞金医院中医科
张宝娣	上海第二医科大学附属瑞金医院中医科
矫桂樯	上海第二医科大学卫生教研室

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中文摘要:

以中药扶正抗癌方为主结合化疗,治疗158例术后晚期胃癌患者。结果:第一批56例随机分为单纯中药与中药加化疗组,平均3、5、10年以上生存率分别为41.07%、30.36%和12.5%;第二批102例以中药加三种不同化疗方案进行治疗,三组3年生存率均超过50%,但以中药加5-Fu 为最佳。动物实验研究表明,该方能抑制或杀灭艾氏腹水瘤癌细胞,使小白鼠生存期显著延长。本研究通过中药微量元素测定,机体免疫功能试验及天然杀伤(NK)细胞活性测定,探讨了该方的抗癌作用机理。

英文摘要:

158 cases of late gastric carcinoma(111 males and 47 females,age 30～70 years)were treated postoperatively with TCM prescriptions of strengthening the patient’s resistance and dispelling the invading evil in combination with chemotherapy.The main ingredients were Radix Codonopsis Pilosulae,Radix Astragali seu Hedysari,Rhizoma Atractylodes,Herba Solani Hyrati,Herbs Oldenlandiae and Herbs Salviae.The prescription was individualized by adding or substracting some herbs according to TCM syndrome diagnosis at the time of patient’s visit.The decoction was given daily for a long time,three to four years or even longer.It was given alone or together with regimes of chemotherapy at random.The average survival rates at 3 and 5 years were 41.07% and 30.36% respectively.Seven patients have lived for more than 11 years.10 years survival rate was 12.5%.The combination of Chinese medicine with chemotherapy was better than chemotherapy regime alone (single 5-Fu or CCNU+5-Fu,MMF).Immunological studies of the survivors revealed an enhance- ment of both humoral and cellular immunity especially the function of peripheral NK cells. The decoction had been given to mice bearing Enrlich ascites tumor.The amount of ascitic fluid was reduced and its cancer cell count decreased besides a significant increase in over-all survival rate of the animals.It suggested that the above prescription might have an inhibitory or even killing effect on tumor cells.T cell immunity of the treated mice was also improved as seen among patients.

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